methyl 3-(5-tert-butyl-2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate

Base Information

Chemical Name:methyl 3-(5-tert-butyl-2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate
CAS No.:1491155-54-4
Molecular Formula:C₂₇H₂₇NO₅
Molecular Weight:445.515
Hs Code.:

Synonyms:methyl 3-(5-tert-butyl-2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate

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Chemical Property of methyl 3-(5-tert-butyl-2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate

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Technology Process of methyl 3-(5-tert-butyl-2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate

There total 5 articles about methyl 3-(5-tert-butyl-2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.6%

: 98-54-4
para-tert-butylphenol

: 1491155-34-0
methyl 3-hydroxy-3-(4-methoxyphenyl)-2-oxindoline-7-carboxylate

: 1491155-54-4
methyl 3-(5-tert-butyl-2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; for 1.5h; Cooling with ice; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.08.030

Reference yield:

: 134-20-3
2-carbomethoxyaniline

: 1491155-54-4
methyl 3-(5-tert-butyl-2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium sulfate; hydroxylamine hydrochloride; hydrogenchloride / water

2: sulfuric acid / Heating

3: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice

4: trifluorormethanesulfonic acid / dichloromethane / 1.5 h / Cooling with ice; Inert atmosphere

With hydrogenchloride; trifluorormethanesulfonic acid; sulfuric acid; hydroxylamine hydrochloride; sodium sulfate; In tetrahydrofuran; dichloromethane; water; 3: |Grignard Reaction / 4: |Friedel-Crafts Acylation;
DOI:10.1016/j.ejmech.2013.08.030

Reference yield:

: 63016-87-5
methyl 2-{[(hydroxyimino)acetyl]amino}benzoate

: 1491155-54-4
methyl 3-(5-tert-butyl-2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / Heating

2: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice

3: trifluorormethanesulfonic acid / dichloromethane / 1.5 h / Cooling with ice; Inert atmosphere

With trifluorormethanesulfonic acid; sulfuric acid; In tetrahydrofuran; dichloromethane; 2: |Grignard Reaction / 3: |Friedel-Crafts Acylation;
DOI:10.1016/j.ejmech.2013.08.030