Triethylsilanyloxy-acetic acid (1R,2S)-2-phenyl-cyclohexyl ester

Base Information

• Chemical Name: Triethylsilanyloxy-acetic acid (1R,2S)-2-phenyl-cyclohexyl ester
• CAS No.: 195196-20-4
• Molecular Formula: C₂₀H₃₂O₃Si
• Molecular Weight: 348.558
• Mol file: 195196-20-4.mol

Synonyms:Triethylsilanyloxy-acetic acid (1R,2S)-2-phenyl-cyclohexyl ester

Chemical Property of Triethylsilanyloxy-acetic acid (1R,2S)-2-phenyl-cyclohexyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of Triethylsilanyloxy-acetic acid (1R,2S)-2-phenyl-cyclohexyl ester

There total 1 articles about Triethylsilanyloxy-acetic acid (1R,2S)-2-phenyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

triethylsilyl chloride (994-30-9) + (-)-(1R,2S)-2-phenyl-1-cyclohexyl hydroxyacetate (143843-06-5) → Triethylsilanyloxy-acetic acid (1R,2S)-2-phenyl-cyclohexyl ester (195196-20-4)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jo971009v

Reference yield: 96.0%

[4-(benzylideneamino)phenyl]methanol (783-08-4) + Triethylsilanyloxy-acetic acid (1R,2S)-2-phenyl-cyclohexyl ester (195196-20-4) → (3S,4R)-1-(4-Methoxy-phenyl)-4-phenyl-3-triisopropylsilanyloxy-azetidin-2-one (618428-34-5)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1016/S0968-0896(03)00181-0

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) + Triethylsilanyloxy-acetic acid (1R,2S)-2-phenyl-cyclohexyl ester (195196-20-4) → {(1S,2R)-2-[(Z)-1-(tert-Butyl-dimethyl-silanyloxy)-2-triethylsilanyloxy-vinyloxy]-cyclohexyl}-benzene (199433-91-5) + {(1S,2R)-2-[(E)-1-(tert-Butyl-dimethyl-silanyloxy)-2-triethylsilanyloxy-vinyloxy]-cyclohexyl}-benzene

Guidance literature:

With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; at -100 - 20 ℃; for 0.166667h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo971009v

upstream raw materials:

triethylsilyl chloride

(-)-(1R,2S)-2-phenyl-1-cyclohexyl hydroxyacetate

Downstream raw materials:

{(1S,2R)-2-[(Z)-1-(tert-Butyl-dimethyl-silanyloxy)-2-triethylsilanyloxy-vinyloxy]-cyclohexyl}-benzene

(3S,4R)-1-(4-Methoxy-phenyl)-4-phenyl-3-triisopropylsilanyloxy-azetidin-2-one