(S,R)-1-(4-benzyl-morpholin-2-yl)-2-(2-methoxy-phenyl)-1-phenyl-ethanol

Base Information

• Chemical Name: (S,R)-1-(4-benzyl-morpholin-2-yl)-2-(2-methoxy-phenyl)-1-phenyl-ethanol
• CAS No.: 800407-77-6
• Molecular Formula: C₂₆H₂₉NO₃
• Molecular Weight: 403.521
• Mol file: 800407-77-6.mol

Synonyms:(S,R)-1-(4-benzyl-morpholin-2-yl)-2-(2-methoxy-phenyl)-1-phenyl-ethanol

Chemical Property of (S,R)-1-(4-benzyl-morpholin-2-yl)-2-(2-methoxy-phenyl)-1-phenyl-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,R)-1-(4-benzyl-morpholin-2-yl)-2-(2-methoxy-phenyl)-1-phenyl-ethanol

There total 2 articles about (S,R)-1-(4-benzyl-morpholin-2-yl)-2-(2-methoxy-phenyl)-1-phenyl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-benzyl-morpholin-2-yl)-phenylmethanone (521969-46-0) + o-Methoxybenzyl chloride (7035-02-1) → (S,R)-1-(4-benzyl-morpholin-2-yl)-2-(2-methoxy-phenyl)-1-phenyl-ethanol (800407-77-6)

Guidance literature:

o-Methoxybenzyl chloride; With magnesium; In diethyl ether; ethylene dibromide; at 15 - 20 ℃; for 0.5h;

(4-benzyl-morpholin-2-yl)-phenylmethanone; In diethyl ether; 1,1-Dibromoethane; at -20 - 20 ℃; for 2h;

Reference yield:

(2S)-(4-benzyl-morpholin-2-yl)-phenyl-methanone (664361-10-8) + o-Methoxybenzyl chloride (7035-02-1) + magnesium (7439-95-4) → (S,R)-1-(4-benzyl-morpholin-2-yl)-2-(2-methoxy-phenyl)-1-phenyl-ethanol (800407-77-6)

Guidance literature:

o-Methoxybenzyl chloride; magnesium; ethylene dibromide; In diethyl ether; at 15 - 20 ℃; for 0.5h;

(2S)-(4-benzyl-morpholin-2-yl)-phenyl-methanone; In diethyl ether;

Reference yield: 75.0%

(S,R)-1-(4-benzyl-morpholin-2-yl)-2-(2-methoxy-phenyl)-1-phenyl-ethanol (800407-77-6) → (S, R)-2-(2-methoxy-phenyl)-1-morpholin-2-yl-1-phenyl-ethanol hydrochloride

Guidance literature:

(S,R)-1-(4-benzyl-morpholin-2-yl)-2-(2-methoxy-phenyl)-1-phenyl-ethanol; With ammonium formate; palladium on activated carbon; In ethyl acetate; at 20 ℃; for 1h; Heating / reflux;

With hydrogenchloride; In diethyl ether; ethanol;

upstream raw materials:

(2S)-(4-benzyl-morpholin-2-yl)-phenyl-methanone

o-Methoxybenzyl chloride

magnesium

(4-benzyl-morpholin-2-yl)-phenylmethanone