3-(2-methoxy-4-methylphenyl)-8-methoxy-1,4-naphthoquinone-2-carboxylic acid

Base Information

Chemical Name:3-(2-methoxy-4-methylphenyl)-8-methoxy-1,4-naphthoquinone-2-carboxylic acid
CAS No.:139976-06-0
Molecular Formula:C₂₀H₁₆O₆
Molecular Weight:352.343
Hs Code.:

Synonyms:3-(2-methoxy-4-methylphenyl)-8-methoxy-1,4-naphthoquinone-2-carboxylic acid

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Chemical Property of 3-(2-methoxy-4-methylphenyl)-8-methoxy-1,4-naphthoquinone-2-carboxylic acid

Chemical Property:

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Technology Process of 3-(2-methoxy-4-methylphenyl)-8-methoxy-1,4-naphthoquinone-2-carboxylic acid

There total 5 articles about 3-(2-methoxy-4-methylphenyl)-8-methoxy-1,4-naphthoquinone-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 139976-04-8
methyl 3-(2-methoxy-4-methylphenyl)-8-methoxy-1,4-naphthoquinone-2-carboxylate

: 139976-07-1
2-hydroxy-3-(2-methoxy-4-methylphenyl)-8-methoxy-1,4-naphthoquinone

: 139976-06-0
3-(2-methoxy-4-methylphenyl)-8-methoxy-1,4-naphthoquinone-2-carboxylic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; for 16h; Heating;
DOI:10.1021/jo00036a005

Reference yield:

: 57415-35-7
2-methoxy-4-methylbenzaldehyde

: 139976-06-0
3-(2-methoxy-4-methylphenyl)-8-methoxy-1,4-naphthoquinone-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / pyridine, piperidine / 1.) 85 deg C, 2 h, 2.) 115 deg C, 2 h

2: 2.1 g / diethyl ether / 0.25 h

3: 1.) LDA / 1.) THF, hexane, -78 deg C, 1 h, 2a.) r. t., 3 h, 2b.) r. t., 6 h

4: 43 percent / aq. KOH / tetrahydrofuran / 16 h / Heating

With piperidine; pyridine; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00036a005

Reference yield:

: 53005-58-6
3-(2-methoxy-4-methylphenyl)propenoic acid

: 139976-06-0
3-(2-methoxy-4-methylphenyl)-8-methoxy-1,4-naphthoquinone-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 2.1 g / diethyl ether / 0.25 h

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 1 h, 2a.) r. t., 3 h, 2b.) r. t., 6 h

3: 43 percent / aq. KOH / tetrahydrofuran / 16 h / Heating

With potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00036a005