4-nitrophenyl 2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate

Base Information

Chemical Name:4-nitrophenyl 2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate
CAS No.:1225276-60-7
Molecular Formula:C₂₂H₂₁F₃N₂O₅
Molecular Weight:450.414
Hs Code.:

Synonyms:4-nitrophenyl 2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate

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Chemical Property of 4-nitrophenyl 2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate

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Technology Process of 4-nitrophenyl 2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate

There total 5 articles about 4-nitrophenyl 2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1225433-11-3
C₁₅H₁₈F₃NO

: 7693-46-1
4-Nitrophenyl chloroformate

: 1225276-60-7
4-nitrophenyl 2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane;
DOI:10.1016/j.bmcl.2011.08.048

Reference yield:

: 240401-28-9
2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester

: 1225276-60-7
4-nitrophenyl 2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran

2: nickel(II) iodide; lithium hexamethyldisilazane / isopropyl alcohol

3: hydrogenchloride / 1,4-dioxane; dichloromethane

4: sodium hydrogencarbonate / 1,4-dioxane

With nickel(II) iodide; hydrogenchloride; carbon tetrabromide; sodium hydrogencarbonate; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; isopropyl alcohol; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.08.048

Reference yield:

: 1225276-07-2
tert-butyl 2-bromo-7-azaspiro[3.5]nonane-7-carboxylate

: 1225276-60-7
4-nitrophenyl 2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: nickel(II) iodide; lithium hexamethyldisilazane / isopropyl alcohol

2: hydrogenchloride / 1,4-dioxane; dichloromethane

3: sodium hydrogencarbonate / 1,4-dioxane

With nickel(II) iodide; hydrogenchloride; sodium hydrogencarbonate; lithium hexamethyldisilazane; In 1,4-dioxane; dichloromethane; isopropyl alcohol; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.08.048