Benzoic acid 3-(2-amino-4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-cyclobutylmethyl ester

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Chemical Name:Benzoic acid 3-(2-amino-4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-cyclobutylmethyl ester
CAS No.:206660-71-1
Molecular Formula:C₁₈H₁₇ClN₄O₂
Molecular Weight:356.812
Hs Code.:

Synonyms:Benzoic acid 3-(2-amino-4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-cyclobutylmethyl ester

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Chemical Property of Benzoic acid 3-(2-amino-4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-cyclobutylmethyl ester

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Technology Process of Benzoic acid 3-(2-amino-4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-cyclobutylmethyl ester

There total 6 articles about Benzoic acid 3-(2-amino-4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-cyclobutylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 84955-31-7
4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine

: 206660-70-0
Benzoic acid 3-benzenesulfonyloxy-cyclobutylmethyl ester

: 206660-71-1
Benzoic acid 3-(2-amino-4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-cyclobutylmethyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; paraffin; at 80 ℃; for 48h;
DOI:10.3987/com-97-s(n)63

Reference yield:

: 141352-63-8
1α-benzyloxy-3β-carbethoxy-cyclobutane

: 206660-71-1
Benzoic acid 3-(2-amino-4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-cyclobutylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / H₂ / Pd on carbon / ethanol / 1551.4 Torr

2: 88 percent / pyridine / 20 h / 0 °C

3: 93.3 percent / NaBH₄, CaCl₂ / ethanol / 0 °C / to RT

4: 77 percent / pyridine / 12 h / Ambient temperature

5: 53 percent / NaH / dimethylformamide; paraffin / 48 h / 80 °C

With pyridine; sodium tetrahydroborate; hydrogen; sodium hydride; calcium chloride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; paraffin;
DOI:10.3987/com-97-s(n)63

Reference yield:

: 98-88-4
benzoyl chloride

: 206660-71-1
Benzoic acid 3-(2-amino-4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-cyclobutylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / pyridine / 12 h / Ambient temperature

2: 53 percent / NaH / dimethylformamide; paraffin / 48 h / 80 °C

With pyridine; sodium hydride; In N,N-dimethyl-formamide; paraffin;
DOI:10.3987/com-97-s(n)63