Ethyl 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-(4-formylphenyl)isoxazole-3-carboxylate

Base Information

• Chemical Name: Ethyl 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-(4-formylphenyl)isoxazole-3-carboxylate
• CAS No.: 1133784-44-7
• Molecular Formula: C₃₆H₃₃NO₆
• Molecular Weight: 575.661
• Mol file: 1133784-44-7.mol

Synonyms:Ethyl 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-(4-formylphenyl)isoxazole-3-carboxylate

Chemical Property of Ethyl 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-(4-formylphenyl)isoxazole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of Ethyl 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-(4-formylphenyl)isoxazole-3-carboxylate

There total 1 articles about Ethyl 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-(4-formylphenyl)isoxazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

ethyl-5-(2,4-dibenzyloxy-5-isopropylphenyl)-4-iodoisoxazole-3-carboxylate (1133784-43-6) + 4-formylphenylboronic acid, (87199-17-5) → Ethyl 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-(4-formylphenyl)isoxazole-3-carboxylate (1133784-44-7)

Guidance literature:

With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; at 80 ℃;

Reference yield: 73.0%

morpholine (110-91-8,99108-56-2) + Ethyl 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-(4-formylphenyl)isoxazole-3-carboxylate (1133784-44-7) → ethyl 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxylate (1133784-45-8)

Guidance literature:

morpholine; Ethyl 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-(4-formylphenyl)isoxazole-3-carboxylate; With magnesium sulfate; acetic acid; In dichloromethane; for 2h;

With sodium cyanoborohydride; In dichloromethane;

upstream raw materials:

ethyl-5-(2,4-dibenzyloxy-5-isopropylphenyl)-4-iodoisoxazole-3-carboxylate

4-formylphenylboronic acid,

Downstream raw materials:

ethyl 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxylate

Refernces