C₇₀H₉₅N₅O₁₇

Base Information

• Chemical Name: C₇₀H₉₅N₅O₁₇
• CAS No.: 339570-95-5
• Molecular Formula: C₇₀H₉₅N₅O₁₇
• Molecular Weight: 1278.55
• Mol file: 339570-95-5.mol

Synonyms:C₇₀H₉₅N₅O₁₇

Chemical Property of C₇₀H₉₅N₅O₁₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₇₀H₉₅N₅O₁₇

There total 20 articles about C₇₀H₉₅N₅O₁₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S,4S)-4-(benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-2,5-dimethyl-3-hexanol (126587-67-5) → C70H95N5O17 (339570-95-5)

Guidance literature:

Multi-step reaction with 11 steps

1: 96 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h

2: 44 percent / LiAlH₄ / diethyl ether / 2 h / -10 °C

3: 98 percent / DIEA / CH₂Cl₂ / 20 °C

4: 89 percent / HCO₂H / Pd / methanol / 0.33 h

5: 47 percent / DMAP; DCC / toluene

6: 94 percent / Amberlyst 15 / methanol / 20 h

7: Dess-Martin reagent / CH₂Cl₂ / 4 h

8: NaClO₂; 5percent NaH₂PO₄ / dimethylsulfoxide; acetonitrile

9: 94.1 mg / DMAP; DCC / CH₂Cl₂

10: Me₃P; H₂O / tetrahydrofuran; toluene / 1 h

11: 95 mg / HATU; collidine / dimethylformamide

With 2,3,5-trimethyl-pyridine; dmap; sodium chlorite; lithium aluminium tetrahydride; formic acid; Amberlyst 15; water; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; trimethylphosphane; palladium; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile; 7: Dess-Martin oxidation;

DOI:10.1021/jo001640n

Reference yield:

(2R,4S)-4-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-2,5-dimethyl-hexan-3-one (339570-88-6) → C70H95N5O17 (339570-95-5)

Guidance literature:

Multi-step reaction with 10 steps

1: 44 percent / LiAlH₄ / diethyl ether / 2 h / -10 °C

2: 98 percent / DIEA / CH₂Cl₂ / 20 °C

3: 89 percent / HCO₂H / Pd / methanol / 0.33 h

4: 47 percent / DMAP; DCC / toluene

5: 94 percent / Amberlyst 15 / methanol / 20 h

6: Dess-Martin reagent / CH₂Cl₂ / 4 h

7: NaClO₂; 5percent NaH₂PO₄ / dimethylsulfoxide; acetonitrile

8: 94.1 mg / DMAP; DCC / CH₂Cl₂

9: Me₃P; H₂O / tetrahydrofuran; toluene / 1 h

10: 95 mg / HATU; collidine / dimethylformamide

With 2,3,5-trimethyl-pyridine; dmap; sodium chlorite; lithium aluminium tetrahydride; formic acid; Amberlyst 15; water; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; trimethylphosphane; palladium; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile; 6: Dess-Martin oxidation;

DOI:10.1021/jo001640n

Reference yield:

(2R,3R,4S)-4-(benzyloxy)-1-[(tert-butyldimethylsilyl)oxy]-2,5-dimethyl-3-hexanol (339570-89-7) → C70H95N5O17 (339570-95-5)

Guidance literature:

Multi-step reaction with 9 steps

1: 98 percent / DIEA / CH₂Cl₂ / 20 °C

2: 89 percent / HCO₂H / Pd / methanol / 0.33 h

3: 47 percent / DMAP; DCC / toluene

4: 94 percent / Amberlyst 15 / methanol / 20 h

5: Dess-Martin reagent / CH₂Cl₂ / 4 h

6: NaClO₂; 5percent NaH₂PO₄ / dimethylsulfoxide; acetonitrile

7: 94.1 mg / DMAP; DCC / CH₂Cl₂

8: Me₃P; H₂O / tetrahydrofuran; toluene / 1 h

9: 95 mg / HATU; collidine / dimethylformamide

With 2,3,5-trimethyl-pyridine; dmap; sodium chlorite; formic acid; Amberlyst 15; water; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; trimethylphosphane; palladium; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile; 5: Dess-Martin oxidation;

DOI:10.1021/jo001640n

upstream raw materials:

(2R,3S,4S)-4-(benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-2,5-dimethyl-3-hexanol

acetic acid (6S)-(10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-(1R)-cyclohex-2-enyl ester

(1R,5S,8S)-8-hydroxy-7-oxa-bicyclo[3.2.1]-octan-6-one

(1S,2R)-2-hydroxy-3-cyclohexanecarboxylic acid

Downstream raw materials:

cyclo-[N-(tert-butyloxycarbonyl)-O-[[N-[(2S,3R,4S)-4-[(1S,2S,3S)-3-amino-2-benzyloxycyclohexanecarbonyl]oxy-3-(methoxymethoxy)-2,5-dimethylhexanoyl]-L-leucyl]-L-prolyl-N,O-dimethyl-L-tyrosyl]-L-threonyl]