339570-89-7

Upstream product

• 126587-67-5 (2R,3S,4S)-4-(benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-2,5-dimethyl-3-hexanol 
• 339570-88-6 (2R,4S)-4-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-2,5-dimethyl-hexan-3-one 

Downstream Products

• 339570-95-5 C₇₀H₉₅N₅O₁₇ 
• 339570-96-6 cyclo-[N-(tert-butyloxycarbonyl)-O-[[N-[(2S,3R,4S)-4-[(1S,2S,3S)-3-amino-2-benzyloxycyclohexanecarbonyl]oxy-3-(methoxymethoxy)-2,5-dimethylhexanoyl]-L-leucyl]-L-prolyl-N,O-dimethyl-L-tyrosyl]-L-threonyl] 
• 339570-92-2 (1S,2R,3R)-4-[(tert-butyldimethylsilyl)oxy]-1-isopropyl-2-(methoxymethoxy)-3-methylbutyl (1S,2S,3S)-3-azido-2-benzyloxy-cyclohexanecarboxylate 
• 339570-94-4 (1S,2R,3R)-1-isopropyl-2-(methoxymethoxy)-3-methylbutanoic benzyl ester, ester with (1S,2S,3S)-3-azido-2-benzyloxycyclohexanecarboxylate 
• 1026914-48-6 (1S,2S,3S)-3-Amino-2-benzyloxy-cyclohexanecarboxylic acid (1S,2R,3S)-3-benzyloxycarbonyl-1-isopropyl-2-methoxymethoxy-butyl ester 
• 339570-93-3 (1S,2R,3R)-1-isopropyl-2-(methoxymethoxy)-3-methylbutan-4-ol (1S,2S,3S)-3-azido-2-benzyloxy-cyclohexanecarboxylate 
• 339570-90-0 ((2R,3R,4S)-4-Benzyloxy-3-methoxymethoxy-2,5-dimethyl-hexyloxy)-tert-butyl-dimethyl-silane 

Relevant academic research and scientific papers

Total synthesis of a conformationally constrained didemnin B analog

The total synthesis of a didemnin B analogue containing a conformationally constrained replacement for the isostatine moiety is reported. Synthetic highlights include an improved preparation of 2-hydroxy-3-cyclohexenecarboxylic acid and a new strategy for accessing the macrocycle.