4-[4-(5-[1,1'-biphenyl]-2-yl-4,5-dihydro-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperidinecarboxamide

Base Information

Chemical Name:4-[4-(5-[1,1'-biphenyl]-2-yl-4,5-dihydro-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperidinecarboxamide
CAS No.:1173697-64-7
Molecular Formula:C₃₂H₃₂N₄O₂S
Molecular Weight:536.698
Hs Code.:

Synonyms:4-[4-(5-[1,1'-biphenyl]-2-yl-4,5-dihydro-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperidinecarboxamide

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Chemical Property of 4-[4-(5-[1,1'-biphenyl]-2-yl-4,5-dihydro-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperidinecarboxamide

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Technology Process of 4-[4-(5-[1,1'-biphenyl]-2-yl-4,5-dihydro-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperidinecarboxamide

There total 5 articles about 4-[4-(5-[1,1'-biphenyl]-2-yl-4,5-dihydro-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1173697-81-8
1-(5-[1,1'-biphenyl]-2-yl-4,5-dihydro-3-isoxazolyl)-2-chloroethanone

: 1148046-80-3
4-(aminothioxomethyl)-N-(2,5-dimethylphenyl)-1-piperidinecarboxamide

: 1173697-64-7
4-[4-(5-[1,1'-biphenyl]-2-yl-4,5-dihydro-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperidinecarboxamide

Guidance literature:: 1-(5-[1,1'-biphenyl]-2-yl-4,5-dihydro-3-isoxazolyl)-2-chloroethanone; 4-(aminothioxomethyl)-N-(2,5-dimethylphenyl)-1-piperidinecarboxamide; With sodium bromide; In acetonitrile; Reflux;

With sodium hydrogencarbonate; In water;

Reference yield:

: 1203-68-5
2-Phenylbenzaldehyde

: 1173697-64-7
4-[4-(5-[1,1'-biphenyl]-2-yl-4,5-dihydro-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C

2: sodium hydrogencarbonate / acetonitrile / 48 h / 20 °C

3: sodium bromide / acetonitrile / Reflux

With potassium tert-butylate; sodium hydrogencarbonate; sodium bromide; In tetrahydrofuran; acetonitrile;

Reference yield:

: 4395-98-6
4-cyanopiperidine

: 1173697-64-7
4-[4-(5-[1,1'-biphenyl]-2-yl-4,5-dihydro-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether / 0.5 h / 0 °C / Cooling with ice-water bath

2: sodium hydrosulfide hydrate; diethyl amine hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C

3: sodium bromide / acetonitrile / Reflux

With sodium hydrosulfide hydrate; diethyl amine hydrochloride; sodium bromide; In diethyl ether; N,N-dimethyl-formamide; acetonitrile;