2-bromo-6-(trimethylsilyl)phenyl trifluoromethanesulfonate

Base Information

Chemical Name:2-bromo-6-(trimethylsilyl)phenyl trifluoromethanesulfonate
CAS No.:1092542-31-8
Molecular Formula:C₁₀H₁₂BrF₃O₃SSi
Molecular Weight:377.254
Hs Code.:

Synonyms:2-bromo-6-(trimethylsilyl)phenyl trifluoromethanesulfonate

Suppliers and Price of 2-bromo-6-(trimethylsilyl)phenyl trifluoromethanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
2-Bromo-6-(trimethylsilyl)phenyl triflate 95%
250mg
$ 64.70

Sigma-Aldrich
2-Bromo-6-(trimethylsilyl)phenyl triflate 95%
1g
$ 234.00

AK Scientific
2-Bromo-6-(trimethylsilyl)phenyl triflate
250mg
$ 123.00

Total 5 raw suppliers

Chemical Property of 2-bromo-6-(trimethylsilyl)phenyl trifluoromethanesulfonate

Chemical Property:

Refractive Index:n/D1.492
Boiling Point:340.6±42.0 °C(Predicted)
Density:1.482 g/L at 25 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-6-(trimethylsilyl)phenyl triflate 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Bromosilyltriflate has been shown to be a useful precursor for the generation of a bromobenzyne intermediate. The bromobenzyne intermediate can be generated in the presence of cesium or potassium fluoride and can be trapped with various dipolariphiles.

Technology Process of 2-bromo-6-(trimethylsilyl)phenyl trifluoromethanesulfonate

There total 4 articles about 2-bromo-6-(trimethylsilyl)phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 58144-45-9
2,6-dibromophenol O-trimethylsilyl ether

: 1092542-31-8
2-bromo-6-(trimethylsilyl)phenyl trifluoromethanesulfonate

Guidance literature:: 2,6-dibromophenol O-trimethylsilyl ether; With n-butyllithium; In diethyl ether; at 20 ℃; for 0.0166667h; Flow reactor;

trifluoromethylsulfonic anhydride; In diethyl ether; at 20 ℃; for 0.00202778h; Flow reactor;
DOI:10.1021/ol500959e

Reference yield: 72.0%

: 75-77-4
chloro-trimethyl-silane

: 358-23-6
trifluoromethylsulfonic anhydride

: 608-33-3
2,6-dibromophenol

: 1092542-31-8
2-bromo-6-(trimethylsilyl)phenyl trifluoromethanesulfonate

Guidance literature:: 2,6-dibromophenol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.0833333h; Inert atmosphere;

chloro-trimethyl-silane; In tetrahydrofuran; mineral oil; for 2h; Inert atmosphere;

trifluoromethylsulfonic anhydride; Further stages;
DOI:10.1021/jacs.8b01005

Reference yield: 69.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 58144-49-3
2-bromo-6-(trimethylsilyl)phenol

: 1092542-31-8
2-bromo-6-(trimethylsilyl)phenyl trifluoromethanesulfonate

Guidance literature:: 2-bromo-6-(trimethylsilyl)phenol; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.333333h; Inert atmosphere;

trifluoromethylsulfonic anhydride; In tetrahydrofuran; at -78 - 20 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1039/c7ob01596h