N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline methyl ester

Base Information

• Chemical Name: N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline methyl ester
• CAS No.: 104849-08-3
• Molecular Formula: C₃₈H₅₂N₄O₉
• Molecular Weight: 708.852

Synonyms:N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline methyl ester

Chemical Property of N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline methyl ester

Chemical Property:

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Technology Process of N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline methyl ester

There total 2 articles about N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester (2578-84-9) + CH3CO2(1-)*H3N-D-Ala-Asu(OtBu)-D-Pro-OMe(1+) (104848-90-0) → N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline methyl ester (104849-08-3)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 2h; Yield given; Ambient temperature;

DOI:10.1021/jm00384a013

Reference yield:

CH3CO2(1-)*H3N-D-Ala-Asu(OtBu)-D-Pro-OMe(1+) (104848-90-0) → N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline methyl ester (104849-08-3)

Guidance literature:

benzotriazol-1-ol;

DOI:10.1016/S0040-4039(00)96315-9

Reference yield: 66.0%

N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline methyl ester (104849-08-3) → N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline (104849-09-4)

Guidance literature:

With sodium hydroxide; In methanol; Ambient temperature;

DOI:10.1021/jm00384a013

upstream raw materials:

N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester

CH₃CO₂^(1-)*H₃N-D-Ala-Asu(O^tBu)-D-Pro-OMe⁽¹⁺⁾

Downstream raw materials:

N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline

L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline acetate salt

6-((5S,8R,11S,13aR)-11-Benzyl-8-methyl-4,7,10,13-tetraoxo-tetradecahydro-3a,6,9,12-tetraaza-cyclopentacyclododecen-5-yl)-hexanoic acid

cyclo

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