N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline

Base Information

Chemical Name:N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline
CAS No.:104849-09-4
Molecular Formula:C₃₇H₅₀N₄O₉
Molecular Weight:694.825
Hs Code.:

Synonyms:N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline

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Chemical Property of N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline

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Technology Process of N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline

There total 1 articles about N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 104849-08-3
N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline methyl ester

: 104849-09-4
N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline

Guidance literature:: With sodium hydroxide; In methanol; Ambient temperature;
DOI:10.1021/jm00384a013

Reference yield: 83.0%

: 104849-09-4
N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline

: 64-19-7,77671-22-8
acetic acid

: 104849-11-8
L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline acetate salt

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 3h;
DOI:10.1021/jm00384a013

Reference yield:

: 104849-09-4
N-(benzyloxycarbonyl)-L-phenylalanyl-D-alanyl-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-D-proline

: 104994-59-4
6-((5S,8R,11S,13aR)-11-Benzyl-8-methyl-4,7,10,13-tetraoxo-tetradecahydro-3a,6,9,12-tetraaza-cyclopentacyclododecen-5-yl)-hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / H₂ / 10percent Pd/C / methanol / 3 h

2: 11 percent / Et₃N, bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl) / CH₂Cl₂ / 64 h / -10 - 20 °C

3: TFA / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00384a013