(3R)-1-azabicyclo[2.2.2]oct-3-yl (2-phenyl-3-thienyl)carbamate hydrochloride

Base Information

Chemical Name:(3R)-1-azabicyclo[2.2.2]oct-3-yl (2-phenyl-3-thienyl)carbamate hydrochloride
CAS No.:1047672-62-7
Molecular Formula:C₁₈H₂₀N₂O₂S*ClH
Molecular Weight:364.896
Hs Code.:

Synonyms:(3R)-1-azabicyclo[2.2.2]oct-3-yl (2-phenyl-3-thienyl)carbamate hydrochloride

Suppliers and Price of (3R)-1-azabicyclo[2.2.2]oct-3-yl (2-phenyl-3-thienyl)carbamate hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R)-1-azabicyclo[2.2.2]oct-3-yl (2-phenyl-3-thienyl)carbamate hydrochloride

Chemical Property:

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Technology Process of (3R)-1-azabicyclo[2.2.2]oct-3-yl (2-phenyl-3-thienyl)carbamate hydrochloride

There total 6 articles about (3R)-1-azabicyclo[2.2.2]oct-3-yl (2-phenyl-3-thienyl)carbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₁H₇NOS

: 25333-42-0
(R)-quinuclidin-3-ol

: 1047672-62-7
(3R)-1-azabicyclo[2.2.2]oct-3-yl (2-phenyl-3-thienyl)carbamate hydrochloride

Guidance literature:: C₁₁H₇NOS; (R)-quinuclidin-3-ol; In N,N-dimethyl-formamide; toluene; for 2h; Reflux;

With hydrogenchloride; In ethanol; ethyl acetate;
DOI:10.1016/j.bmc.2014.04.031

Reference yield:

: 38695-70-4
methyl 2-phenylthiophene-3-carboxylate

: 1047672-62-7
(3R)-1-azabicyclo[2.2.2]oct-3-yl (2-phenyl-3-thienyl)carbamate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / ethanol / 6 h / Reflux

2: triethylamine; diphenyl phosphoryl azide / toluene / 0.67 h / 20 °C

3: toluene / 1 h / 90 °C

4: toluene; N,N-dimethyl-formamide / 2 h / Reflux

With diphenyl phosphoryl azide; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; toluene; 3: |Curtius Rearrangement;
DOI:10.1016/j.bmc.2014.04.031

Reference yield:

: 38695-73-7
2-phenylthiophene-3-carboxylic acid

: 1047672-62-7
(3R)-1-azabicyclo[2.2.2]oct-3-yl (2-phenyl-3-thienyl)carbamate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; diphenyl phosphoryl azide / toluene / 0.67 h / 20 °C

2: toluene / 1 h / 90 °C

3: toluene; N,N-dimethyl-formamide / 2 h / Reflux

With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; toluene; 2: |Curtius Rearrangement;
DOI:10.1016/j.bmc.2014.04.031