5-((1R,2S)-2-aminocyclohexylamino)-3-(3-morpholino-5-(1H-pyrazol-1-yl)phenylamino)pyrazine-2-carboxamide

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Chemical Name:5-((1R,2S)-2-aminocyclohexylamino)-3-(3-morpholino-5-(1H-pyrazol-1-yl)phenylamino)pyrazine-2-carboxamide
CAS No.:1438419-63-6
Molecular Formula:C₂₄H₃₁N₉O₂
Molecular Weight:477.569
Hs Code.:

Synonyms:5-((1R,2S)-2-aminocyclohexylamino)-3-(3-morpholino-5-(1H-pyrazol-1-yl)phenylamino)pyrazine-2-carboxamide

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Chemical Property of 5-((1R,2S)-2-aminocyclohexylamino)-3-(3-morpholino-5-(1H-pyrazol-1-yl)phenylamino)pyrazine-2-carboxamide

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Technology Process of 5-((1R,2S)-2-aminocyclohexylamino)-3-(3-morpholino-5-(1H-pyrazol-1-yl)phenylamino)pyrazine-2-carboxamide

There total 5 articles about 5-((1R,2S)-2-aminocyclohexylamino)-3-(3-morpholino-5-(1H-pyrazol-1-yl)phenylamino)pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1438423-72-3
tert-butyl ((1S,2R)-2-((6-chloro-5-cyanopyrazin-2-yl)amino)cyclohexyl)carbamate

: 1438424-24-8
3-morpholino-5-(1H-pyrazol-1-yl)aniline

: 1438419-63-6
5-((1R,2S)-2-aminocyclohexylamino)-3-(3-morpholino-5-(1H-pyrazol-1-yl)phenylamino)pyrazine-2-carboxamide

Guidance literature:: tert-butyl ((1S,2R)-2-((6-chloro-5-cyanopyrazin-2-yl)amino)cyclohexyl)carbamate; 3-morpholino-5-(1H-pyrazol-1-yl)aniline; With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 115 ℃; for 3h; Inert atmosphere;

With trifluoroacetic acid; at 20 ℃; for 0.5h;

With dihydrogen peroxide; potassium hydroxide; In methanol; dimethyl sulfoxide; at 20 ℃; for 0.5h;

Reference yield:

: 626-40-4
3,5-dibromoaniline

: 1438419-63-6
5-((1R,2S)-2-aminocyclohexylamino)-3-(3-morpholino-5-(1H-pyrazol-1-yl)phenylamino)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: iron(III)-acetylacetonate; copper(II) acetate monohydrate; caesium carbonate / N,N-dimethyl-formamide / 72 h / 135 °C / Sealed tube

2.1: rac-Pro-OH; potassium phosphate; copper(l) iodide / dimethyl sulfoxide / 96 h / 120 °C / Sealed tube

3.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate; palladium diacetate / 1,4-dioxane / 3 h / 115 °C / Inert atmosphere

3.2: 0.5 h / 20 °C

3.3: 0.5 h / 20 °C

With potassium phosphate; copper(l) iodide; iron(III)-acetylacetonate; palladium diacetate; copper(II) acetate monohydrate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; rac-Pro-OH; In 1,4-dioxane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1000289-46-2
3-bromo-5-(1H-pyrazol-1-yl)aniline

: 1438419-63-6
5-((1R,2S)-2-aminocyclohexylamino)-3-(3-morpholino-5-(1H-pyrazol-1-yl)phenylamino)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: rac-Pro-OH; potassium phosphate; copper(l) iodide / dimethyl sulfoxide / 96 h / 120 °C / Sealed tube

2.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate; palladium diacetate / 1,4-dioxane / 3 h / 115 °C / Inert atmosphere

2.2: 0.5 h / 20 °C

2.3: 0.5 h / 20 °C

With potassium phosphate; copper(l) iodide; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; rac-Pro-OH; In 1,4-dioxane; dimethyl sulfoxide;