ethyl [2-(4-cyanophenyl)-5-(4-(dimethylamino)phenyl)]oxazole-4-carboxylate

Base Information

Chemical Name:ethyl [2-(4-cyanophenyl)-5-(4-(dimethylamino)phenyl)]oxazole-4-carboxylate
CAS No.:1334553-27-3
Molecular Formula:C₂₁H₁₉N₃O₃
Molecular Weight:361.4
Hs Code.:

Synonyms:ethyl [2-(4-cyanophenyl)-5-(4-(dimethylamino)phenyl)]oxazole-4-carboxylate

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Chemical Property of ethyl [2-(4-cyanophenyl)-5-(4-(dimethylamino)phenyl)]oxazole-4-carboxylate

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Technology Process of ethyl [2-(4-cyanophenyl)-5-(4-(dimethylamino)phenyl)]oxazole-4-carboxylate

There total 3 articles about ethyl [2-(4-cyanophenyl)-5-(4-(dimethylamino)phenyl)]oxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 3058-39-7
4-iodobenzonitrile

: 1283902-09-9
ethyl 5-(4-(N,N-dimethylamino)phenyl)oxazole-4-carboxylate

: 1334553-27-3
ethyl [2-(4-cyanophenyl)-5-(4-(dimethylamino)phenyl)]oxazole-4-carboxylate

Guidance literature:: With palladium diacetate; caesium carbonate; [1,3-bis(2,4,6-trimethylphenyl)imidazol]-2-ylidene; In 1,4-dioxane; at 110 ℃; for 18h; Inert atmosphere;
DOI:10.1039/c1ob05261f

Reference yield:

: 4755-50-4
4-(dimethylamino)benzoyl chloride

: 1334553-27-3
ethyl [2-(4-cyanophenyl)-5-(4-(dimethylamino)phenyl)]oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / Inert atmosphere; Cooling with ice

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: palladium diacetate; caesium carbonate; [1,3-bis(2,4,6-trimethylphenyl)imidazol]-2-ylidene / 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

With potassium tert-butylate; palladium diacetate; caesium carbonate; [1,3-bis(2,4,6-trimethylphenyl)imidazol]-2-ylidene; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1039/c1ob05261f

Reference yield:

: 2999-46-4
Ethyl isocyanoacetate

: 1334553-27-3
ethyl [2-(4-cyanophenyl)-5-(4-(dimethylamino)phenyl)]oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / Inert atmosphere; Cooling with ice

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: palladium diacetate; caesium carbonate; [1,3-bis(2,4,6-trimethylphenyl)imidazol]-2-ylidene / 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

With potassium tert-butylate; palladium diacetate; caesium carbonate; [1,3-bis(2,4,6-trimethylphenyl)imidazol]-2-ylidene; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1039/c1ob05261f