N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonyl-4(R)-hydroxy-L-proline

Base Information

Chemical Name:N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonyl-4(R)-hydroxy-L-proline
CAS No.:104197-70-8
Molecular Formula:C₂₃H₃₆N₂O₇Si
Molecular Weight:480.634
Hs Code.:

Synonyms:N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonyl-4(R)-hydroxy-L-proline

Suppliers and Price of N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonyl-4(R)-hydroxy-L-proline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonyl-4(R)-hydroxy-L-proline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonyl-4(R)-hydroxy-L-proline

There total 12 articles about N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonyl-4(R)-hydroxy-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 104197-69-5
N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonine 2-pyridyl thiol ester

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 104197-70-8
N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonyl-4(R)-hydroxy-L-proline

Guidance literature:: With triethylamine; 1-(Trimethylsilyl)imidazole;
DOI:10.1021/ja00279a065

Reference yield:

: 19728-63-3
N-benzyloxycarbonyl-L-treonine

: 104197-70-8
N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonyl-4(R)-hydroxy-L-proline

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / imidazole / dimethylformamide / 14 h / Ambient temperature

2: 92 percent / PPh₃ / CH₂Cl₂ / 14 h / Ambient temperature

3: 1) 1-(trimethylsilyl)imidazole, NEt₃ / 1) DMF, 2.5 h, RT, 2) RT, 16 h

With 1H-imidazole; triethylamine; 1-(Trimethylsilyl)imidazole; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)87959-X

Reference yield:

: 94820-26-5
(2S,3R)-2-(benzyloxycarbonylamino)-3-tertiary-butyldimethylsilyloxybutanoic acid

: 104197-70-8
N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonyl-4(R)-hydroxy-L-proline

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / PPh₃ / CH₂Cl₂ / 14 h / Ambient temperature

2: 1) 1-(trimethylsilyl)imidazole, NEt₃ / 1) DMF, 2.5 h, RT, 2) RT, 16 h

With triethylamine; 1-(Trimethylsilyl)imidazole; triphenylphosphine; In dichloromethane;
DOI:10.1016/S0040-4020(01)87959-X