N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonine 2-pyridyl thiol ester

Base Information

• Chemical Name: N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonine 2-pyridyl thiol ester
• CAS No.: 104197-69-5
• Molecular Formula: C₂₃H₃₂N₂O₄SSi
• Molecular Weight: 460.67

Synonyms:N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonine 2-pyridyl thiol ester

Chemical Property of N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonine 2-pyridyl thiol ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonine 2-pyridyl thiol ester

There total 3 articles about N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonine 2-pyridyl thiol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,2'-dipyridyldisulphide (2127-03-9) + (2S,3R)-2-(benzyloxycarbonylamino)-3-tertiary-butyldimethylsilyloxybutanoic acid (94820-26-5) → N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonine 2-pyridyl thiol ester (104197-69-5)

Guidance literature:

With triphenylphosphine; In dichloromethane;

DOI:10.1021/ja00279a065

Reference yield:

N-benzyloxycarbonyl-L-treonine (19728-63-3) → N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonine 2-pyridyl thiol ester (104197-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / imidazole / dimethylformamide / 14 h / Ambient temperature

2: 92 percent / PPh₃ / CH₂Cl₂ / 14 h / Ambient temperature

With 1H-imidazole; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)87959-X

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonine 2-pyridyl thiol ester (104197-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / imidazole / dimethylformamide / 14 h / Ambient temperature

2: 92 percent / PPh₃ / CH₂Cl₂ / 14 h / Ambient temperature

With 1H-imidazole; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)87959-X

upstream raw materials:

2,2'-dipyridyldisulphide

(2S,3R)-2-(benzyloxycarbonylamino)-3-tertiary-butyldimethylsilyloxybutanoic acid

N-benzyloxycarbonyl-L-treonine

tert-butyldimethylsilyl chloride

Downstream raw materials:

N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonyl-4(R)-hydroxy-L-proline

N^α-linoleyl-N^δ-(tert-butoxycarbonyl)-L-ornithinyl-O-(tert-butyldimethylsilyl)-L-threonyl-4(R)-hydroxy-L-prolyl-3(R)-hydroxy-L-homotyrosinyl-L-threonyl-3(S)-hydroxy-4(S)-methyl-L-proline methyl ester

N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonyl-4(R)-hydroxy-L-prolyl-3(R)-hydroxy-L-homotyrosinyl-L-threonyl-3(S)-hydroxy-4(S)-methyl-L-proline amide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 104197-69-5 N-(benzyloxycarbonyl)-O-(tert-butyldimethylsilyl)-L-threonine 2-pyridyl thiol ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send