benzyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-(3-chlorophenyl)-1H-indole-1-carboxylate

Base Information

Chemical Name:benzyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-(3-chlorophenyl)-1H-indole-1-carboxylate
CAS No.:1393131-21-9
Molecular Formula:C₃₇H₂₆ClNO₄
Molecular Weight:584.071
Hs Code.:

Synonyms:benzyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-(3-chlorophenyl)-1H-indole-1-carboxylate

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Chemical Property of benzyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-(3-chlorophenyl)-1H-indole-1-carboxylate

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Technology Process of benzyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-(3-chlorophenyl)-1H-indole-1-carboxylate

There total 6 articles about benzyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-(3-chlorophenyl)-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1393131-05-9
benzyl (3-chlorobenzoyl)(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)carbamate

: 98-88-4
benzoyl chloride

: 1393131-21-9
benzyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-(3-chlorophenyl)-1H-indole-1-carboxylate

Guidance literature:: With tributylphosphine; triethylamine; In dichloromethane; at 20 ℃; for 1.5h; chemoselective reaction; Inert atmosphere;
DOI:10.1039/c2cc33972b

Reference yield:

: (2-formyl-phenyl)-carbamic acid benzyl ester

: 1393131-21-9
benzyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-(3-chlorophenyl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 12 h / 80 °C / Inert atmosphere

2: dmap; triethylamine / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

3: tributylphosphine; triethylamine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

With dmap; tributylphosphine; triethylamine; In tetrahydrofuran; dichloromethane; toluene; 3: Wittig reaction;
DOI:10.1039/c2cc33972b

Reference yield:

: 111881-64-2
(2-hydroxymethyl-phenyl)-carbamic acid benzyl ester

: 1393131-21-9
benzyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-(3-chlorophenyl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: toluene / 12 h / 80 °C / Inert atmosphere

3: dmap; triethylamine / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

4: tributylphosphine; triethylamine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

With dmap; tributylphosphine; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; toluene; 4: Wittig reaction;
DOI:10.1039/c2cc33972b