4-(2-methoxyphenyl) 1-[3-(5-methyl-1H-indol-3-yl)-1-oxopropyl]piperazine

Base Information

Chemical Name:4-(2-methoxyphenyl) 1-[3-(5-methyl-1H-indol-3-yl)-1-oxopropyl]piperazine
CAS No.:290832-40-5
Molecular Formula:C₂₃H₂₇N₃O₂
Molecular Weight:377.486
Hs Code.:

Synonyms:4-(2-methoxyphenyl) 1-[3-(5-methyl-1H-indol-3-yl)-1-oxopropyl]piperazine

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Chemical Property of 4-(2-methoxyphenyl) 1-[3-(5-methyl-1H-indol-3-yl)-1-oxopropyl]piperazine

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Technology Process of 4-(2-methoxyphenyl) 1-[3-(5-methyl-1H-indol-3-yl)-1-oxopropyl]piperazine

There total 3 articles about 4-(2-methoxyphenyl) 1-[3-(5-methyl-1H-indol-3-yl)-1-oxopropyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 7394-79-8
3-(5-methyl-1H-indol-3-yl)propanoic acid

: 5464-78-8
1-(2-methoxyphenyl)piperazine hydrochloride

: 290832-40-5
4-(2-methoxyphenyl) 1-[3-(5-methyl-1H-indol-3-yl)-1-oxopropyl]piperazine

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran;
DOI:10.1016/S0960-894X(01)00183-4

Reference yield:

: 614-96-0
5-methyl-1H-indole

: 290832-40-5
4-(2-methoxyphenyl) 1-[3-(5-methyl-1H-indol-3-yl)-1-oxopropyl]piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / Ac₂O; AcOH / 168 h / 20 °C

2: HOBt; Et₃N; EDC / tetrahydrofuran / 16 h / 20 °C

With acetic anhydride; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran;
DOI:10.1016/S0960-894X(01)00182-2

Reference yield:

: 290832-40-5
4-(2-methoxyphenyl) 1-[3-(5-methyl-1H-indol-3-yl)-1-oxopropyl]piperazine

Guidance literature:: With benzotriazol-1-ol; triethylamine; In tetrahydrofuran; at 20 ℃; for 0.166667h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 2h;