methyl 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid ester

Base Information

Chemical Name:methyl 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid ester
CAS No.:142374-15-0
Molecular Formula:C₃₁H₄₂N₂O₇
Molecular Weight:554.684
Hs Code.:

methyl 2-(S)-<N-<(benzyloxy)carbonyl>amino>-3-<4-<<<N-<(tert-butyloxy)carbonyl>piperidin-4-yl>propyl>oxy>phenyl>propionic acid ester

Synonyms:methyl 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid ester

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Chemical Property of methyl 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid ester

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Technology Process of methyl 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid ester

There total 4 articles about methyl 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 13512-31-7
N-(benzyloxycarbonyl)-L-tyrosine methyl ester

: 142374-14-9
4-(3-iodo-propyl)-piperidine-1-carboxylic acid tert-butyl ester

: 142374-15-0
methyl 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; for 20h; Ambient temperature;
DOI:10.1021/jm00042a007

Reference yield:

: 2629-72-3
4-(3-Hydroxypropyl)pyridine

: 142374-15-0
methyl 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / H₂ / 10percent Pd/C / acetic acid / 48 h / 2585.7 Torr

2: 73 percent / NaOH / dioxane / 18 h

3: 78 percent / imidazol, I₂, triphenylphosphine chloride / toluene / 1.5 h

4: 27 percent / cesium carbonate / dimethylformamide / 20 h / Ambient temperature

With 1H-imidazole; sodium hydroxide; hydrogen; iodine; caesium carbonate; dichlorotriphenylphosphorane; palladium on activated charcoal; In 1,4-dioxane; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00042a007

Reference yield:

: 7037-49-2
3-(piperidin-4-yl)propan-1-ol

: 142374-15-0
methyl 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid ester

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / NaOH / dioxane / 18 h

2: 78 percent / imidazol, I₂, triphenylphosphine chloride / toluene / 1.5 h

3: 27 percent / cesium carbonate / dimethylformamide / 20 h / Ambient temperature

With 1H-imidazole; sodium hydroxide; iodine; caesium carbonate; dichlorotriphenylphosphorane; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00042a007