1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane

Base Information

Chemical Name:1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane
CAS No.:1057107-31-9
Molecular Formula:C₃₄H₅₈N₄O₈
Molecular Weight:650.857
Hs Code.:

Synonyms:1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane

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Chemical Property of 1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane

Chemical Property:

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Technology Process of 1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane

There total 6 articles about 1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1057107-33-1
2,5,8-tris(tert-butoxycarbonylmethyl)-3-(4-tert-butyloxycarbonylaminobenzyl)-1,9-diphenyl-2,5,8-triazanonane

: 1057107-31-9
1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane

Guidance literature:: With ammonium formate; palladium on activated charcoal; In methanol; for 0.25h; Heating;
DOI:10.1016/j.bmcl.2006.06.088

Reference yield:

: 2-(benzylidene-amino)-N-[2-(benzylidene-amino)-ethyl]-3-(4-nitro-phenyl)-propionamide

: 1057107-31-9
1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane

Guidance literature:: Multi-step reaction with 5 steps

1.1: BH₃ / tetrahydrofuran / Heating

1.2: aq. HCl / tetrahydrofuran / 3 h / Heating

2.1: 79 percent / DIPEA / dimethylformamide / 20 °C

3.1: 58 percent / NaBH₄ / Pd/C / methanol / 0.5 h / 20 °C

4.1: 92 percent / TEA / acetonitrile / 2 h / 20 °C

5.1: 75 percent / ammonium formate / Pd/C / methanol / 0.25 h / Heating

With sodium tetrahydroborate; TEA; borane; ammonium formate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2006.06.088

Reference yield:

: 1057107-27-3
3-(4-nitrobenzyl)-1,9-diphenyl-2,5,8-triazanonane

: 1057107-31-9
1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / DIPEA / dimethylformamide / 20 °C

2: 58 percent / NaBH₄ / Pd/C / methanol / 0.5 h / 20 °C

3: 92 percent / TEA / acetonitrile / 2 h / 20 °C

4: 75 percent / ammonium formate / Pd/C / methanol / 0.25 h / Heating

With sodium tetrahydroborate; TEA; ammonium formate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2006.06.088