1,7-bis(aminocarbonylmethyl)-1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane

Base Information

Chemical Name:1,7-bis(aminocarbonylmethyl)-1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane
CAS No.:1057107-26-2
Molecular Formula:C₃₈H₆₄N₆O₁₀
Molecular Weight:764.96
Hs Code.:

Synonyms:1,7-bis(aminocarbonylmethyl)-1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane

Suppliers and Price of 1,7-bis(aminocarbonylmethyl)-1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,7-bis(aminocarbonylmethyl)-1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,7-bis(aminocarbonylmethyl)-1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane

There total 7 articles about 1,7-bis(aminocarbonylmethyl)-1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1057107-31-9
1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane

: 144-48-9
iodacetamide

: 1057107-26-2
1,7-bis(aminocarbonylmethyl)-1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane

Guidance literature:: With potassium carbonate; In acetonitrile; for 2h; Heating;
DOI:10.1016/j.bmcl.2006.06.088

Reference yield:

: 2-(benzylidene-amino)-N-[2-(benzylidene-amino)-ethyl]-3-(4-nitro-phenyl)-propionamide

: 1057107-26-2
1,7-bis(aminocarbonylmethyl)-1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane

Guidance literature:: Multi-step reaction with 6 steps

1.1: BH₃ / tetrahydrofuran / Heating

1.2: aq. HCl / tetrahydrofuran / 3 h / Heating

2.1: 79 percent / DIPEA / dimethylformamide / 20 °C

3.1: 58 percent / NaBH₄ / Pd/C / methanol / 0.5 h / 20 °C

4.1: 92 percent / TEA / acetonitrile / 2 h / 20 °C

5.1: 75 percent / ammonium formate / Pd/C / methanol / 0.25 h / Heating

6.1: 86 percent / K₂CO₃ / acetonitrile / 2 h / Heating

With sodium tetrahydroborate; TEA; borane; ammonium formate; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2006.06.088

Reference yield:

: 1057107-27-3
3-(4-nitrobenzyl)-1,9-diphenyl-2,5,8-triazanonane

: 1057107-26-2
1,7-bis(aminocarbonylmethyl)-1,4,7-tris(tert-butoxycarbonylmethyl)-2-(4-tert-butyloxycarbonylaminobenzyl)-1,4,7-triazaheptane

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / DIPEA / dimethylformamide / 20 °C

2: 58 percent / NaBH₄ / Pd/C / methanol / 0.5 h / 20 °C

3: 92 percent / TEA / acetonitrile / 2 h / 20 °C

4: 75 percent / ammonium formate / Pd/C / methanol / 0.25 h / Heating

5: 86 percent / K₂CO₃ / acetonitrile / 2 h / Heating

With sodium tetrahydroborate; TEA; ammonium formate; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2006.06.088