2,5,8-tris(tert-butoxycarbonylmethyl)-3-(4-tert-butyloxycarbonylaminobenzyl)-1,9-diphenyl-2,5,8-triazanonane

Base Information

Chemical Name:2,5,8-tris(tert-butoxycarbonylmethyl)-3-(4-tert-butyloxycarbonylaminobenzyl)-1,9-diphenyl-2,5,8-triazanonane
CAS No.:1057107-33-1
Molecular Formula:C₄₈H₇₀N₄O₈
Molecular Weight:831.106
Hs Code.:

Synonyms:2,5,8-tris(tert-butoxycarbonylmethyl)-3-(4-tert-butyloxycarbonylaminobenzyl)-1,9-diphenyl-2,5,8-triazanonane

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Chemical Property of 2,5,8-tris(tert-butoxycarbonylmethyl)-3-(4-tert-butyloxycarbonylaminobenzyl)-1,9-diphenyl-2,5,8-triazanonane

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Technology Process of 2,5,8-tris(tert-butoxycarbonylmethyl)-3-(4-tert-butyloxycarbonylaminobenzyl)-1,9-diphenyl-2,5,8-triazanonane

There total 6 articles about 2,5,8-tris(tert-butoxycarbonylmethyl)-3-(4-tert-butyloxycarbonylaminobenzyl)-1,9-diphenyl-2,5,8-triazanonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1057107-30-8
2,5,8-tris(tert-butoxycarbonylmethyl)-3-(4-aminobenzyl)-1,9-diphenyl-2,5,8-triazanonane

: 24424-99-5
di-tert-butyl dicarbonate

: 1057107-33-1
2,5,8-tris(tert-butoxycarbonylmethyl)-3-(4-tert-butyloxycarbonylaminobenzyl)-1,9-diphenyl-2,5,8-triazanonane

Guidance literature:: With TEA; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2006.06.088

Reference yield:

: 2-(benzylidene-amino)-N-[2-(benzylidene-amino)-ethyl]-3-(4-nitro-phenyl)-propionamide

: 1057107-33-1
2,5,8-tris(tert-butoxycarbonylmethyl)-3-(4-tert-butyloxycarbonylaminobenzyl)-1,9-diphenyl-2,5,8-triazanonane

Guidance literature:: Multi-step reaction with 4 steps

1.1: BH₃ / tetrahydrofuran / Heating

1.2: aq. HCl / tetrahydrofuran / 3 h / Heating

2.1: 79 percent / DIPEA / dimethylformamide / 20 °C

3.1: 58 percent / NaBH₄ / Pd/C / methanol / 0.5 h / 20 °C

4.1: 92 percent / TEA / acetonitrile / 2 h / 20 °C

With sodium tetrahydroborate; TEA; borane; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2006.06.088

Reference yield:

: 1057107-27-3
3-(4-nitrobenzyl)-1,9-diphenyl-2,5,8-triazanonane

: 1057107-33-1
2,5,8-tris(tert-butoxycarbonylmethyl)-3-(4-tert-butyloxycarbonylaminobenzyl)-1,9-diphenyl-2,5,8-triazanonane

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / DIPEA / dimethylformamide / 20 °C

2: 58 percent / NaBH₄ / Pd/C / methanol / 0.5 h / 20 °C

3: 92 percent / TEA / acetonitrile / 2 h / 20 °C

With sodium tetrahydroborate; TEA; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2006.06.088