6-Chloro-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Base Information

Chemical Name:6-Chloro-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS No.:23789-98-2
Molecular Formula:C₁₁H₈ClNO₃
Molecular Weight:237.642
Hs Code.:
European Community (EC) Number:857-690-9

Synonyms:6-chloro-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;23789-98-2;6-chloro-1-methyl-4-oxoquinoline-3-carboxylic acid;LJLOUFZTLYUARB-UHFFFAOYSA-N;BBL030983;STK653362;AKOS002337082;VS-10160;DB-113951;CS-0247135;EN300-35777;G19350;Z361906374;6-chloro-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylicacid;6-Chloro-1-methyl-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid;6-chloro-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, AldrichCPR

Suppliers and Price of 6-Chloro-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
6-CHLORO-1-METHYL-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID 95.00%
10G
$ 2483.25

American Custom Chemicals Corporation
6-CHLORO-1-METHYL-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID 95.00%
5G
$ 1697.85

American Custom Chemicals Corporation
6-CHLORO-1-METHYL-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID 95.00%
1G
$ 1062.60

Total 1 raw suppliers

Chemical Property of 6-Chloro-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:237.0192708
Heavy Atom Count:16
Complexity:366

Purity/Quality:: 6-CHLORO-1-METHYL-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22

MSDS Files:

Useful:

Canonical SMILES:CN1C=C(C(=O)C2=C1C=CC(=C2)Cl)C(=O)O

Technology Process of 6-Chloro-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

There total 1 articles about 6-Chloro-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23789-98-2
6-chloro-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Ethylester, 10percent-ig. wss. KOH, 1 h kochen;

Reference yield: 88.0%

: 2-(trifluoromethyl)biphenyl-4-amine

: 23789-98-2
6-chloro-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

: 1351945-35-1
6-chloro-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 - 50 ℃; for 32h;
DOI:10.1021/ml200252b

Reference yield:

: 23789-98-2
6-chloro-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

: 1351945-36-2
1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-6-vinyl-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 32 h / 20 - 50 °C

2: bis(tri-t-butylphosphine)palladium⁽⁰⁾; tri-tert-butyl phosphine; cesium fluoride / 1,4-dioxane; hexane / 20 h / 100 °C / Inert atmosphere

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; tri-tert-butyl phosphine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; cesium fluoride; In 1,4-dioxane; hexane; N,N-dimethyl-formamide;
DOI:10.1021/ml200252b