6-(hydroxymethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

Base Information

Chemical Name:6-(hydroxymethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide
CAS No.:1351945-10-2
Molecular Formula:C₂₅H₁₉F₃N₂O₃
Molecular Weight:452.433
Hs Code.:

Synonyms:6-(hydroxymethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

Suppliers and Price of 6-(hydroxymethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-(hydroxymethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-(hydroxymethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

There total 5 articles about 6-(hydroxymethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1351945-37-3
6-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-1,4-dihydroquinoline-3-carboxamide

: 1351945-10-2
6-(hydroxymethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

Guidance literature:: With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;
DOI:10.1021/ml200252b

Reference yield:

: 2-(trifluoromethyl)biphenyl-4-amine

: 1351945-10-2
6-(hydroxymethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 32 h / 20 - 50 °C

2: bis(tri-t-butylphosphine)palladium⁽⁰⁾; tri-tert-butyl phosphine; cesium fluoride / 1,4-dioxane; hexane / 20 h / 100 °C / Inert atmosphere

3: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water / 4 h / 0 °C

4: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 0.25 h / 0 °C

With sodium periodate; osmium(VIII) oxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; tri-tert-butyl phosphine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; lithium tri-t-butoxyaluminum hydride; triethylamine; cesium fluoride; In tetrahydrofuran; 1,4-dioxane; hexane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml200252b

Reference yield:

: 1351945-35-1
6-chloro-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

: 1351945-10-2
6-(hydroxymethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; tri-tert-butyl phosphine; cesium fluoride / 1,4-dioxane; hexane / 20 h / 100 °C / Inert atmosphere

2: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water / 4 h / 0 °C

3: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 0.25 h / 0 °C

With sodium periodate; osmium(VIII) oxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; tri-tert-butyl phosphine; lithium tri-t-butoxyaluminum hydride; cesium fluoride; In tetrahydrofuran; 1,4-dioxane; hexane; water;
DOI:10.1021/ml200252b