6-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-1,4-dihydroquinoline-3-carboxamide

Base Information

Chemical Name:6-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-1,4-dihydroquinoline-3-carboxamide
CAS No.:1351945-37-3
Molecular Formula:C₂₅H₁₇F₃N₂O₃
Molecular Weight:450.417
Hs Code.:

Synonyms:6-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-1,4-dihydroquinoline-3-carboxamide

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Chemical Property of 6-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-1,4-dihydroquinoline-3-carboxamide

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Technology Process of 6-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-1,4-dihydroquinoline-3-carboxamide

There total 4 articles about 6-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-1,4-dihydroquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351945-36-2
1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-6-vinyl-1,4-dihydroquinoline-3-carboxamide

: 1351945-37-3
6-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: With sodium periodate; osmium(VIII) oxide; In tetrahydrofuran; water; at 0 ℃; for 4h;
DOI:10.1021/ml200252b

Reference yield:

: 2-(trifluoromethyl)biphenyl-4-amine

: 1351945-37-3
6-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 32 h / 20 - 50 °C

2: bis(tri-t-butylphosphine)palladium⁽⁰⁾; tri-tert-butyl phosphine; cesium fluoride / 1,4-dioxane; hexane / 20 h / 100 °C / Inert atmosphere

3: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water / 4 h / 0 °C

With sodium periodate; osmium(VIII) oxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; tri-tert-butyl phosphine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; cesium fluoride; In tetrahydrofuran; 1,4-dioxane; hexane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml200252b

Reference yield:

: 1351945-35-1
6-chloro-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

: 1351945-37-3
6-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; tri-tert-butyl phosphine; cesium fluoride / 1,4-dioxane; hexane / 20 h / 100 °C / Inert atmosphere

2: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water / 4 h / 0 °C

With sodium periodate; osmium(VIII) oxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; tri-tert-butyl phosphine; cesium fluoride; In tetrahydrofuran; 1,4-dioxane; hexane; water;
DOI:10.1021/ml200252b