α-((4-chlorobenzenesulfonyl)((4-t-butyloxycarbonylphenyl)methyl)amino)-3,5-difluorobenzeneacetamide

Base Information

Chemical Name:α-((4-chlorobenzenesulfonyl)((4-t-butyloxycarbonylphenyl)methyl)amino)-3,5-difluorobenzeneacetamide
CAS No.:1194751-18-2
Molecular Formula:C₂₆H₂₅ClF₂N₂O₅S
Molecular Weight:551.011
Hs Code.:

Synonyms:α-((4-chlorobenzenesulfonyl)((4-t-butyloxycarbonylphenyl)methyl)amino)-3,5-difluorobenzeneacetamide

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Chemical Property of α-((4-chlorobenzenesulfonyl)((4-t-butyloxycarbonylphenyl)methyl)amino)-3,5-difluorobenzeneacetamide

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Technology Process of α-((4-chlorobenzenesulfonyl)((4-t-butyloxycarbonylphenyl)methyl)amino)-3,5-difluorobenzeneacetamide

There total 9 articles about α-((4-chlorobenzenesulfonyl)((4-t-butyloxycarbonylphenyl)methyl)amino)-3,5-difluorobenzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1194752-29-8
α-(4-chlorobenzenesulfonylamino)-3,5-difluorobenzeneacetamide

: 143726-85-6
4-hydroxymethylbenzoic acid tert-butyl ester

: 1194751-18-2
α-((4-chlorobenzenesulfonyl)((4-t-butyloxycarbonylphenyl)methyl)amino)-3,5-difluorobenzeneacetamide

Guidance literature:: α-(4-chlorobenzenesulfonylamino)-3,5-difluorobenzeneacetamide; With di-isopropyl azodicarboxylate; In tetrahydrofuran; at 0 ℃; for 0.25h; Inert atmosphere;

4-hydroxymethylbenzoic acid tert-butyl ester; With triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 18.25h; Inert atmosphere;

Reference yield:

: methyl α-azido-3,5-difluorobenzeneacetate

: 1194751-18-2
α-((4-chlorobenzenesulfonyl)((4-t-butyloxycarbonylphenyl)methyl)amino)-3,5-difluorobenzeneacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / 2585.81 Torr

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

3.2: 18.08 h / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C / Inert atmosphere

5.1: triethylamine / acetonitrile / 50 h / 0 - 20 °C

6.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

6.2: 18.25 h / 0 - 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; water; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 210530-70-4
methyl 2-(3,5-difluorophenyl)acetate

: 1194751-18-2
α-((4-chlorobenzenesulfonyl)((4-t-butyloxycarbonylphenyl)methyl)amino)-3,5-difluorobenzeneacetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 18 h / Inert atmosphere; Reflux

2.1: sodium azide / acetonitrile / 20.5 h / 20 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / 2585.81 Torr

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

5.2: 18.08 h / 0 - 20 °C

6.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C / Inert atmosphere

7.1: triethylamine / acetonitrile / 50 h / 0 - 20 °C

8.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

8.2: 18.25 h / 0 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; sodium azide; 2,2'-azobis(isobutyronitrile); di-isopropyl azodicarboxylate; water; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;