Technology Process of α-(((1,1,-dimethylethoxy)carbonyl)amino)-3,5-difluorobenzeneacetic acid
There total 5 articles about α-(((1,1,-dimethylethoxy)carbonyl)amino)-3,5-difluorobenzeneacetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
α-(((1,1,-dimethylethoxy)carbonyl)amino)-3,5-difluorobenzeneacetic acid methyl ester;
With
water; lithium hydroxide;
In
tetrahydrofuran; methanol;
at 0 - 20 ℃;
for 3h;
With
sodium hydrogen sulfate;
In
water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / 2585.81 Torr
2: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 0 - 20 °C
With
water; hydrogen; lithium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 18 h / Inert atmosphere; Reflux
2: sodium azide / acetonitrile / 20.5 h / 20 °C / Inert atmosphere
3: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / 2585.81 Torr
4: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 0 - 20 °C
With
N-Bromosuccinimide; sodium azide; 2,2'-azobis(isobutyronitrile); water; hydrogen; lithium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; tetrachloromethane; ethyl acetate; acetonitrile;
