2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-trifluoropmethylbenzoic acid methyl ester

Base Information

• Chemical Name: 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-trifluoropmethylbenzoic acid methyl ester
• CAS No.: 1146214-86-9
• Molecular Formula: C₁₅H₁₈BF₃O₄
• Molecular Weight: 330.112

Synonyms:2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-trifluoropmethylbenzoic acid methyl ester

Chemical Property of 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-trifluoropmethylbenzoic acid methyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

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Technology Process of 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-trifluoropmethylbenzoic acid methyl ester

There total 5 articles about 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-trifluoropmethylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 4-(trifluoromethyl)benzoate (2967-66-0) + bis(pinacol)diborane (73183-34-3) → 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-trifluoropmethylbenzoic acid methyl ester (1146214-86-9)

Guidance literature:

With [Ir(OMe)(COD)]2/tris[3,5-bis(CF₃)phenyl]phosphine; In octane; 80°C, 16 h, benzoate ester (5.0 mmol), bis(pinacolato)diboron (1.0 mmol), (Ir(OMe)(COD))2 (0.015 mmol), tris(3,5-bis(trifluoromethyl)phenyl)phosphine (0.06 mmol);

DOI:10.1039/b910298a

Reference yield: 91.0%

methyl 2-bromo-4-(trifluoromethyl)benzoate (1214334-90-3) + bis(pinacol)diborane (73183-34-3) → 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-trifluoropmethylbenzoic acid methyl ester (1146214-86-9)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1055/s-0031-1291048

Reference yield: 79.0%

methyl 4-(trifluoromethyl)benzoate (2967-66-0) + bis(pinacol)diborane (73183-34-3) → 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-trifluoropmethylbenzoic acid methyl ester (1146214-86-9) + methyl 2,6-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzoate (1146215-05-5)

Guidance literature:

With Silica-SMAP-Ir(OMe)(cod); In hexane; at 25 ℃; for 15h; regioselective reaction; Autoclave;

upstream raw materials:

methyl 4-(trifluoromethyl)benzoate

bis(pinacol)diborane

methyl 2-bromo-4-(trifluoromethyl)benzoate

2-amino-4-trifluoromethylbenzoic acid

Downstream raw materials:

2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzoic acid

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