Methyl 2-bromo-4-(trifluoromethyl)benzoate

Base Information

• Chemical Name: Methyl 2-bromo-4-(trifluoromethyl)benzoate
• CAS No.: 1214334-90-3
• Molecular Formula: C9H6BrF3O2
• Molecular Weight: 283.045
• Hs Code.: 2916399090
• Mol file: 1214334-90-3.mol

Synonyms:Methyl 2-bromo-4-(trifluoromethyl)benzoate;2-broMo-4-trifluoroMethylMethyl benzoate;2-Bromo-4-(trifluoromethyl)benzoic acid methyl ester;2-bromo-4- (trifluoromethyl) benzoate

Chemical Property of Methyl 2-bromo-4-(trifluoromethyl)benzoate

Chemical Property:

• Boiling Point: 248.9±40.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.598±0.06 g/cm3(Predicted)
• LogP: 3.25450
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-bromo-4-(trifluoromethyl)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-bromo-4-(trifluoromethyl)benzoate

There total 3 articles about Methyl 2-bromo-4-(trifluoromethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-bromo-4-trifluoromethyl-benzoic acid (328-89-2) + methyl iodide (74-88-4) → methyl 2-bromo-4-(trifluoromethyl)benzoate (1214334-90-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 23 ℃; for 24h; Inert atmosphere;

DOI:10.1055/s-0031-1291048

Reference yield: 68.0%

methanol (67-56-1) + 2-bromo-4-trifluoromethyl-benzoic acid (328-89-2) → methyl 2-bromo-4-(trifluoromethyl)benzoate (1214334-90-3)

Guidance literature:

With sulfuric acid; at 65 ℃; for 19h;

DOI:10.1002/chem.201406290

Reference yield:

2-amino-4-trifluoromethylbenzoic acid (402-13-1) → methyl 2-bromo-4-(trifluoromethyl)benzoate (1214334-90-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen bromide; acetic acid; sodium nitrite / water / 3.08 h / -10 - 0 °C

1.2: 1 h / 60 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 23 °C / Inert atmosphere

With hydrogen bromide; potassium carbonate; acetic acid; sodium nitrite; In water; N,N-dimethyl-formamide;

DOI:10.1055/s-0031-1291048

upstream raw materials:

2-bromo-4-trifluoromethyl-benzoic acid

methyl iodide

2-amino-4-trifluoromethylbenzoic acid

methanol

Downstream raw materials:

2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-trifluoropmethylbenzoic acid methyl ester

2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzoic acid

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