[N-tert-butoxycarbonyl-[2-(dimethylphenylsilanyl)-but-2-enyl]-amino]-acetic acid [1R,2S,5R]-menthol ester

Base Information

Chemical Name:[N-tert-butoxycarbonyl-[2-(dimethylphenylsilanyl)-but-2-enyl]-amino]-acetic acid [1R,2S,5R]-menthol ester
CAS No.:864360-72-5
Molecular Formula:C₂₉H₄₇NO₄Si
Molecular Weight:501.782
Hs Code.:

Synonyms:[N-tert-butoxycarbonyl-[2-(dimethylphenylsilanyl)-but-2-enyl]-amino]-acetic acid [1R,2S,5R]-menthol ester

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Chemical Property of [N-tert-butoxycarbonyl-[2-(dimethylphenylsilanyl)-but-2-enyl]-amino]-acetic acid [1R,2S,5R]-menthol ester

Chemical Property:

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Technology Process of [N-tert-butoxycarbonyl-[2-(dimethylphenylsilanyl)-but-2-enyl]-amino]-acetic acid [1R,2S,5R]-menthol ester

There total 3 articles about [N-tert-butoxycarbonyl-[2-(dimethylphenylsilanyl)-but-2-enyl]-amino]-acetic acid [1R,2S,5R]-menthol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31954-27-5
N-(tert-butoxycarbonyl)glycine methyl ester

: 864360-72-5
[N-tert-butoxycarbonyl-[2-(dimethylphenylsilanyl)-but-2-enyl]-amino]-acetic acid [1R,2S,5R]-menthol ester

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / KH / tetrahydrofuran / 0 - 20 °C

2: 97 percent / aq. NaOH / tetrahydrofuran / 21 h / 20 °C

3: 81 percent / DCC; DMAP / CH₂Cl₂ / 14 h / -30 - 20 °C

With dmap; sodium hydroxide; potassium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b506198a

Reference yield:

: 320618-86-8
N-tert-butoxycarbonyl-N-[2-(dimethylphenylsilanyl)but-2(Z)-enyl]glycine methyl ester

: 864360-72-5
[N-tert-butoxycarbonyl-[2-(dimethylphenylsilanyl)-but-2-enyl]-amino]-acetic acid [1R,2S,5R]-menthol ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / aq. NaOH / tetrahydrofuran / 21 h / 20 °C

2: 81 percent / DCC; DMAP / CH₂Cl₂ / 14 h / -30 - 20 °C

With dmap; sodium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b506198a

Reference yield:

: 320618-66-4
1-bromo-2-(dimethylphenylsilanyl)but-2(E)-ene

: 864360-72-5
[N-tert-butoxycarbonyl-[2-(dimethylphenylsilanyl)-but-2-enyl]-amino]-acetic acid [1R,2S,5R]-menthol ester

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / KH / tetrahydrofuran / 0 - 20 °C

2: 97 percent / aq. NaOH / tetrahydrofuran / 21 h / 20 °C

3: 81 percent / DCC; DMAP / CH₂Cl₂ / 14 h / -30 - 20 °C

With dmap; sodium hydroxide; potassium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b506198a