pent-4-enoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)-methylamide

Base Information

Chemical Name:pent-4-enoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)-methylamide
CAS No.:1071837-46-1
Molecular Formula:C₁₅H₂₁NO₂
Molecular Weight:247.337
Hs Code.:

Synonyms:pent-4-enoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)-methylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of pent-4-enoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)-methylamide

Chemical Property:

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Technology Process of pent-4-enoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)-methylamide

There total 2 articles about pent-4-enoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39716-58-0
pent-4-enoyl chloride

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 1071837-46-1
pent-4-enoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)-methylamide

Guidance literature:: With triethylamine; In tetrahydrofuran; dichloromethane; at 0 ℃; for 1.5h;
DOI:10.1021/ol801849u

Reference yield:

: 591-80-0
pent-4-enoic acid

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 1071837-46-1
pent-4-enoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)-methylamide

Guidance literature:: pent-4-enoic acid; With pivaloyl chloride; triethylamine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

pseudoephedrine; In tetrahydrofuran; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ja2073356

Reference yield: 96.0%

: 6940-76-7
1-iodo-3-chloro-propane

: 1071837-46-1
pent-4-enoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)-methylamide

: 1071837-47-2
(S)-2-(3-chloropropyl)-pent-4-enoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)-methylamide

Guidance literature:: pent-4-enoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)-methylamide; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 - 0 ℃;

1-iodo-3-chloro-propane; In tetrahydrofuran; hexane; at 0 ℃; for 1h; diastereoselective reaction;
DOI:10.1021/ol801849u