(E)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid

Base Information

Chemical Name:(E)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid
CAS No.:1375150-71-2
Molecular Formula:C₁₇H₂₀N₄O₂
Molecular Weight:312.371
Hs Code.:

Synonyms:(E)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid

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Chemical Property of (E)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid

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Technology Process of (E)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid

There total 6 articles about (E)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1254831-47-4
(1-cyclohexyl-1H-imidazol-4-yl)-acetic acid ethyl ester

: 199296-40-7
2-(tert-butyloxycarbonyl)-aminopyridine-5-carboxaldehyde

: 1375150-71-2
(E)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid

Guidance literature:: (1-cyclohexyl-1H-imidazol-4-yl)-acetic acid ethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -70 - -20 ℃; for 0.333333h;

2-(tert-butyloxycarbonyl)-aminopyridine-5-carboxaldehyde; In tetrahydrofuran; at -70 ℃; Further stages;

Reference yield:

: 3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid ethyl ester

: 1375150-71-2
(E)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid

Guidance literature:: 3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid ethyl ester; With hydrogenchloride; water; for 0.333333h; Reflux;

With sodium hydroxide; In water; pH=7;

Reference yield:

: 199296-40-7
2-(tert-butyloxycarbonyl)-aminopyridine-5-carboxaldehyde

: 1375150-71-2
(E)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -70 - -20 °C

1.2: -70 °C

1.3: -20 - 20 °C

2.1: hydrogenchloride; water / 0.33 h / Reflux

2.2: pH 7

With hydrogenchloride; water; lithium hexamethyldisilazane; In tetrahydrofuran;