(1-cyclohexyl-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-acetic acid ethyl ester

Base Information

• Chemical Name: (1-cyclohexyl-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-acetic acid ethyl ester
• CAS No.: 1254831-53-2
• Molecular Formula: C₁₃H₂₀N₂O₂S
• Molecular Weight: 268.38
• Mol file: 1254831-53-2.mol

Synonyms:(1-cyclohexyl-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-acetic acid ethyl ester

Chemical Property of (1-cyclohexyl-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-cyclohexyl-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-acetic acid ethyl ester

There total 1 articles about (1-cyclohexyl-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-cyclohexylamino-3-oxobutyric acid ethyl ester hydrochloride (1254831-51-0) + potassium thioacyanate (333-20-0) → (1-cyclohexyl-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-acetic acid ethyl ester (1254831-53-2)

Guidance literature:

In water; tert-butyl alcohol; at 90 ℃;

Reference yield: 99.0%

(1-cyclohexyl-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-acetic acid ethyl ester (1254831-53-2) → (1-cyclohexyl-1H-imidazol-4-yl)-acetic acid ethyl ester (1254831-47-4)

Guidance literature:

(1-cyclohexyl-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-acetic acid ethyl ester; With dihydrogen peroxide; acetic acid; at 0 - 10 ℃;

With sodium sulfite; In water; Cooling with ice;

With sodium hydrogencarbonate; potassium carbonate; In water; pH=8;

Reference yield:

(1-cyclohexyl-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-acetic acid ethyl ester (1254831-53-2) → (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid (1375150-73-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dihydrogen peroxide; acetic acid / 2.5 h / 0 - 10 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -70 - -20 °C

2.2: -70 °C

2.3: -20 - 20 °C

3.1: hydrogenchloride; water / 0.33 h / Reflux

3.2: pH 7

4.1: sodium methylate; methanol / 2,2,2-trifluoroethanol

4.2: Chenphos / 24 h / 40 °C / 60006 Torr

With hydrogenchloride; methanol; water; dihydrogen peroxide; sodium methylate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 2,2,2-trifluoroethanol;

upstream raw materials:

4-cyclohexylamino-3-oxobutyric acid ethyl ester hydrochloride

potassium thioacyanate

Downstream raw materials:

(1-cyclohexyl-1H-imidazol-4-yl)-acetic acid ethyl ester

(E)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid

(R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid

(Z)-3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid ethyl ester