(3aR,5S,6S,6aR)-5-Benzyloxymethyl-2,2-dimethyl-6-prop-2-ynyloxy-tetrahydro-furo[2,3-d][1,3]dioxole

Base Information

Chemical Name:(3aR,5S,6S,6aR)-5-Benzyloxymethyl-2,2-dimethyl-6-prop-2-ynyloxy-tetrahydro-furo[2,3-d][1,3]dioxole
CAS No.:152734-70-8
Molecular Formula:C₁₈H₂₂O₅
Molecular Weight:318.37
Hs Code.:

Synonyms:(3aR,5S,6S,6aR)-5-Benzyloxymethyl-2,2-dimethyl-6-prop-2-ynyloxy-tetrahydro-furo[2,3-d][1,3]dioxole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3aR,5S,6S,6aR)-5-Benzyloxymethyl-2,2-dimethyl-6-prop-2-ynyloxy-tetrahydro-furo[2,3-d][1,3]dioxole

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Technology Process of (3aR,5S,6S,6aR)-5-Benzyloxymethyl-2,2-dimethyl-6-prop-2-ynyloxy-tetrahydro-furo[2,3-d][1,3]dioxole

There total 5 articles about (3aR,5S,6S,6aR)-5-Benzyloxymethyl-2,2-dimethyl-6-prop-2-ynyloxy-tetrahydro-furo[2,3-d][1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 100-39-0
benzyl bromide

: ((3aR,5S,6S,6aR)-2,2-Dimethyl-6-prop-2-ynyloxy-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-methanol

: 152734-70-8
(3aR,5S,6S,6aR)-5-Benzyloxymethyl-2,2-dimethyl-6-prop-2-ynyloxy-tetrahydro-furo[2,3-d][1,3]dioxole

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; for 8h; Ambient temperature;
DOI:10.1016/S0040-4039(00)79337-3

Reference yield:

: 87-72-9,608-45-7,608-46-8,608-47-9,2460-44-8,6748-95-4,6763-34-4,7261-26-9,7283-06-9,7283-07-0,7296-55-1,7296-56-2,7296-58-4,7296-59-5,7296-60-8,7296-61-9,7296-62-0,7322-30-7,10257-31-5,10257-32-6,10257-33-7,10257-34-8,10257-35-9,19982-83-3,20242-88-0,28697-53-2,36562-42-2,41546-41-2,89299-64-9,107655-34-5,115794-06-4,115794-07-5,130550-15-1,130606-21-2
L-(+)-arabinose

: 152734-70-8
(3aR,5S,6S,6aR)-5-Benzyloxymethyl-2,2-dimethyl-6-prop-2-ynyloxy-tetrahydro-furo[2,3-d][1,3]dioxole

Guidance literature:: Multi-step reaction with 5 steps

1: 55 percent / imidazole / dimethylformamide / 2 h / 60 °C

2: 70 percent / CuSO₄, H₂SO₄ / 24 h / Ambient temperature

3: 86 percent / NaH, imidazole / tetrahydrofuran / 5 h / Ambient temperature

4: 88 percent / Bu₄NF / tetrahydrofuran / 2 h / Ambient temperature

5: 98 percent / NaH, Bu₄NI / tetrahydrofuran / 8 h / Ambient temperature

With 1H-imidazole; sulfuric acid; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; copper(II) sulfate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)79337-3

Reference yield:

: 103763-12-8,103763-13-9
5-O-tert-butyldiphenylsilyl-α,β-L-arabinofuranose

: 152734-70-8
(3aR,5S,6S,6aR)-5-Benzyloxymethyl-2,2-dimethyl-6-prop-2-ynyloxy-tetrahydro-furo[2,3-d][1,3]dioxole

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / CuSO₄, H₂SO₄ / 24 h / Ambient temperature

2: 86 percent / NaH, imidazole / tetrahydrofuran / 5 h / Ambient temperature

3: 88 percent / Bu₄NF / tetrahydrofuran / 2 h / Ambient temperature

4: 98 percent / NaH, Bu₄NI / tetrahydrofuran / 8 h / Ambient temperature

With 1H-imidazole; sulfuric acid; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; copper(II) sulfate; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)79337-3