Technology Process of (2R,3R)-N-(phenylsulfonyl)-3-hydroxyproline
There total 5 articles about (2R,3R)-N-(phenylsulfonyl)-3-hydroxyproline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxygen;
platinum(IV) oxide;
In
water; isopropyl alcohol;
at 60 ℃;
for 18h;
DOI:10.1021/jo00269a023
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, from -40 deg C to room temp., 18 h
2: 80 percent / HCl / methanol / 0.5 h / 0 °C
3: 95 percent / LiBH4 / propan-2-ol / 2 h / -23 °C
4: K2CO3 / methanol / 2 h / Ambient temperature
5: 87 percent / O2 / PtO2 / H2O; propan-2-ol / 18 h / 60 °C
With
hydrogenchloride; lithium borohydride; n-butyllithium; oxygen; potassium carbonate;
platinum(IV) oxide;
In
methanol; water; isopropyl alcohol;
DOI:10.1021/jo00269a023
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 80 percent / HCl / methanol / 0.5 h / 0 °C
2: 95 percent / LiBH4 / propan-2-ol / 2 h / -23 °C
3: K2CO3 / methanol / 2 h / Ambient temperature
4: 87 percent / O2 / PtO2 / H2O; propan-2-ol / 18 h / 60 °C
With
hydrogenchloride; lithium borohydride; oxygen; potassium carbonate;
platinum(IV) oxide;
In
methanol; water; isopropyl alcohol;
DOI:10.1021/jo00269a023
