85828-29-1

Upstream product

• 56-45-1 L-serin 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 88425-32-5 (S)-2-(N-(phenylsulfonyl)amino)-3-oxo-1,7-dihydroxyheptane 
• 119593-24-7 (S)-3-<(phenylsulfonyl)amino>-4-hydroxy-1-(methylthio)-2-butanone 
• 85828-38-2 (S)-5-<(Phenylsulfonyl)amino>-6-hydroxy-4-hexenone 
• 144422-81-1 N-phenylsulphonyl-4-exomethylene-(S)-proline benzylester 
• 119593-77-0 (2R,3R)-N-(phenylsulfonyl)-3-hydroxyproline 
• 119593-55-4 (2R,3S)-3-<(phenylsulfonyl)amino>-2,4-dihydroxy-1-(methylthio)butane 
• 119593-56-5 (2S,3S)-3-<(phenylsulfonyl)amino>-2,4-dihydroxy-1-(methylthio)butane 
• 119593-25-8 (4S,5S)-5-<(phenylsulfonyl)amino>-4,6-dihydroxyhexene 
• 119593-26-9 (4R,5S)-5-<(phenylsulfonyl)amino>-4,6-dihydroxyhexene 
• 119593-52-1 (2S,3S)-3-hydroxy-2-(hydroxymethyl)-1-(phenylsulfonyl)pyrrolidine 
• 119593-53-2 (2S,3R)-3-hydroxy-2-(hydroxymethyl)-1-(phenylsulfonyl)pyrrolidine 
• 119593-50-9 (2S)-2-[(phenylsulfonyl)amino]-5-chloro-1-hydroxy-3-pentanone 
• 119593-51-0 (3R,S,2S)-2-[(phenylsulfonyl)amino]-5-chloro-1,3-dihydroxypentanes 
• 144423-03-0 N-phenylsulphonyl-N-propargyl-O-tetrahydropyranyl-(S)-serine benzylester 

Relevant academic research and scientific papers

Design, synthesis, molecular docking, antimicrobial, and antioxidant activities of new phenylsulfamoyl carboxylic acids of pharmacological interest

The research explores the facile synthesis of some new phenylsulfamoyl carboxylic acids, their molecular docking, antimicrobial, and antioxidant activities. The procedure involved the mild reaction of amino acids with benzenesulfonyl chloride in a medium

New carboxamides bearing benzenesulphonamides: Synthesis, molecular docking and pharmacological properties

Ten new derivatives of benzenesulphonamide bearing carboxamide functionality were synthesized and investigated for their in vitro antimicrobial, antioxidant and in vivo anti-inflammatory activities. Compound 9d inhibited carrageenan induced rat-paw oedema

IMIDAZOLIDINONE DERIVATIVES

The invention is concerned with novel imidazolidinone derivatives of formula (I): wherein R1 to R11 and X are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds bind

N-Acylated α-Amino Acids as Novel Oral Delivery Agents for Proteins

A series of N-acylated α-amino acids were synthesized and shown to improve the oral delivery of two protein drugs, salmon calcitonin (sCT) and interferon-α.Forty-five compounds in this series were tested in vivo in rats and primates.A significant positive

alpha -AMINO ACIDS AS CHIRAL EDUCTS FOR ASYMMETRIC PRODUCTS. A GENERAL SYNTHESIS OF D- alpha -AMINO ACIDS FROM L-SERINE.

A short and chirally efficient synthesis of four D- alpha -amino acids is described with L-serine as the chiral educt. The key C-C bond-forming reactions are the aminoacylations of organometallics with the lithium salt of N-(phenylsulfonyl)-L-serine (2) to give optically pure N-blocked alpha -amino ketones. Reduction of the carbonyl group to carbinol or methylene followed by oxidation of the hydroxymethyl to carboxyl gives the N-blocked D-amino acids. The examples investigated (norleucine, alpha -aminopimelic acid, DOPA, and allothreonine) demonstrate the broad applicability of the method.

α-Amino Acids as Chiral Educts for Asymmetric Products. Aminoacylation of Metallo Alkyls and Alkenyls

α-Amino acids have been developed as educts for the preparation of optically pure α-amino aliphatic ketones.The amino group of the L-amino acid was first blocked as a suitable acyl derivative, namely, acetyl, benzoyl, ethoxycarbonyl, or benzenesulfonyl.Then the lithium carboxylate was formed and treated with alkyl- and alkenyllithium or Grignard reagents.Thus butyl, allyl, and vinyl organometallics were added to the lithium carboxylates of L-α-N-substituted alanine, valine, O-benzyltyrosine, methionine, serine, and ε-(ethoxycarbonyl)lysine to yield the corresponding optically pure ketones, protected as amides, sulfonamides, or carbamates.