1-(Biphenyl-3-ylamino)-cyclohexanecarboxylic acid {(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propyl}-amide

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Chemical Name:1-(Biphenyl-3-ylamino)-cyclohexanecarboxylic acid {(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propyl}-amide
CAS No.:757975-81-8
Molecular Formula:C₃₆H₄₁N₃O₂
Molecular Weight:547.74
Hs Code.:

Synonyms:1-(Biphenyl-3-ylamino)-cyclohexanecarboxylic acid {(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propyl}-amide

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Chemical Property of 1-(Biphenyl-3-ylamino)-cyclohexanecarboxylic acid {(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propyl}-amide

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Technology Process of 1-(Biphenyl-3-ylamino)-cyclohexanecarboxylic acid {(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propyl}-amide

There total 8 articles about 1-(Biphenyl-3-ylamino)-cyclohexanecarboxylic acid {(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 757976-22-0
1-[(biphenyl-3-yl)amino]cyclohexanecarboxylic acid

: 757976-46-8
tert-butyl [(1S)-1-({[4-(benzyloxy)phenyl]amino}methyl)propyl]carbamate

: 757975-81-8
1-(Biphenyl-3-ylamino)-cyclohexanecarboxylic acid {(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propyl}-amide

Guidance literature:: tert-butyl [(1S)-1-({[4-(benzyloxy)phenyl]amino}methyl)propyl]carbamate; With trifluoroacetic acid; In dichloromethane;

1-[(biphenyl-3-yl)amino]cyclohexanecarboxylic acid; With N-[3-(diethylamino)propyl]-N'-ethylcarbodiimide hydrochloride; benzotriazol-1-ol; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.032

Reference yield:

: 882296-91-5
(1-{[(4-benzyloxy-phenyl)-(2-nitro-benzenesulfonyl)-amino]-methyl}-propyl)-carbamic acid tert-butyl ester

: 757975-81-8
1-(Biphenyl-3-ylamino)-cyclohexanecarboxylic acid {(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propyl}-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: PhSH; K₂CO₃ / acetonitrile / 20 °C

2.1: trifluoroacetic acid / CH₂Cl₂

2.2: 84 percent / 1-hydroxybenzotriazole; 1-ethyl-3-[3-(diethylamino)propyl]carbodiimide HCl / dimethylformamide

With potassium carbonate; thiophenol; trifluoroacetic acid; In dichloromethane; acetonitrile; 2.2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.06.032

Reference yield:

: 313067-82-2
N-[4-(benzyloxy)phenyl]-2-nitrobenzenesulfonamide

: 757975-81-8
1-(Biphenyl-3-ylamino)-cyclohexanecarboxylic acid {(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 20 °C

2.1: PhSH; K₂CO₃ / acetonitrile / 20 °C

3.1: trifluoroacetic acid / CH₂Cl₂

3.2: 84 percent / 1-hydroxybenzotriazole; 1-ethyl-3-[3-(diethylamino)propyl]carbodiimide HCl / dimethylformamide

With potassium carbonate; thiophenol; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; acetonitrile; 1.1: Mitsunobu reaction / 3.2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.06.032