N-((2R,3R,4R)-6-Diacetylamino-2,4-diphenyl-3,4-dihydro-2H-thiopyran-3-carbothioyl)-acetamide

Base Information

• Chemical Name: N-((2R,3R,4R)-6-Diacetylamino-2,4-diphenyl-3,4-dihydro-2H-thiopyran-3-carbothioyl)-acetamide
• CAS No.: 128596-14-5
• Molecular Formula: C₂₄H₂₄N₂O₃S₂
• Molecular Weight: 452.598

Synonyms:N-((2R,3R,4R)-6-Diacetylamino-2,4-diphenyl-3,4-dihydro-2H-thiopyran-3-carbothioyl)-acetamide

Chemical Property of N-((2R,3R,4R)-6-Diacetylamino-2,4-diphenyl-3,4-dihydro-2H-thiopyran-3-carbothioyl)-acetamide

Chemical Property:

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Technology Process of N-((2R,3R,4R)-6-Diacetylamino-2,4-diphenyl-3,4-dihydro-2H-thiopyran-3-carbothioyl)-acetamide

There total 3 articles about N-((2R,3R,4R)-6-Diacetylamino-2,4-diphenyl-3,4-dihydro-2H-thiopyran-3-carbothioyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.4%

(E)-3-phenylprop-2-enethioamide (20314-83-4) + acetyl chloride (75-36-5) → cinnamic nitrile (1885-38-7) + N-((2R,3R,4R)-6-Diacetylamino-2,4-diphenyl-3,4-dihydro-2H-thiopyran-3-carbothioyl)-acetamide (128596-14-5)

Guidance literature:

In pyridine; acetone; for 18h; Heating;

DOI:10.1016/S0040-4020(01)89147-X

Reference yield:

cinnamamide (621-79-4,22031-64-7) → N-((2R,3R,4R)-6-Diacetylamino-2,4-diphenyl-3,4-dihydro-2H-thiopyran-3-carbothioyl)-acetamide (128596-14-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / phosphorus pentasulphide / pyridine / 0.58 h / Heating

2: 40.4 percent / pyridine; acetone / 18 h / Heating

With diphosphorus pentasulfide; In pyridine; acetone;

DOI:10.1016/S0040-4020(01)89147-X

Reference yield:

(E)-3-phenylprop-2-enethioamide (20314-83-4) + acetyl chloride (75-36-5) → N-((2R,3R,4R)-6-Diacetylamino-2,4-diphenyl-3,4-dihydro-2H-thiopyran-3-carbothioyl)-acetamide (128596-14-5)

Guidance literature:

In pyridine; acetone; for 18h; Mechanism; Heating;

DOI:10.1016/S0040-4020(01)89147-X

upstream raw materials:

(E)-3-phenylprop-2-enethioamide

acetyl chloride

cinnamamide

Downstream raw materials:

N-Acetyl-N-((4R,5S,6S)-5-cyano-4,6-diphenyl-5,6-dihydro-4H-thiopyran-2-yl)-acetamide

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