Technology Process of (+/-)-3-(6-(3-methyl-1-(4-(6-methylpyridin-3-yl)phenyl)butylamino)nicotinamido)propanoic acid
There total 5 articles about (+/-)-3-(6-(3-methyl-1-(4-(6-methylpyridin-3-yl)phenyl)butylamino)nicotinamido)propanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / 100 °C
3.1: potassium carbonate / polystyrene triphenylphosphine palladium(0) / 1,2-dimethoxyethane; water / 1 h / 100 °C / Microwave
4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 18 h / 60 °C
5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 18 h / 20 °C
5.2: polystyrene trisamine / 18 h / 20 °C
6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
With
water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide;
polystyrene triphenylphosphine palladium(0);
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / 100 °C
2.1: potassium carbonate / polystyrene triphenylphosphine palladium(0) / 1,2-dimethoxyethane; water / 1 h / 100 °C / Microwave
3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 18 h / 60 °C
4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 18 h / 20 °C
4.2: polystyrene trisamine / 18 h / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
With
water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide;
polystyrene triphenylphosphine palladium(0);
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;
