N-(2-(4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-5-(4-(trifluoromethyl)phenyl)isoxazol-3-amine

Base Information

Chemical Name:N-(2-(4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-5-(4-(trifluoromethyl)phenyl)isoxazol-3-amine
CAS No.:1554015-86-9
Molecular Formula:C₃₄H₃₆ClF₃N₄O₂
Molecular Weight:625.134
Hs Code.:

Synonyms:N-(2-(4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-5-(4-(trifluoromethyl)phenyl)isoxazol-3-amine

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Chemical Property of N-(2-(4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-5-(4-(trifluoromethyl)phenyl)isoxazol-3-amine

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Technology Process of N-(2-(4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-5-(4-(trifluoromethyl)phenyl)isoxazol-3-amine

There total 15 articles about N-(2-(4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-5-(4-(trifluoromethyl)phenyl)isoxazol-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1554015-85-8
(Z)-3-(2-(4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenylamino)-3-(methylthio)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one

: 1554015-86-9
N-(2-(4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-5-(4-(trifluoromethyl)phenyl)isoxazol-3-amine

Guidance literature:: With hydroxylamine; In ethanol; at 85 ℃; for 18h;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1554015-86-9
N-(2-(4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-5-(4-(trifluoromethyl)phenyl)isoxazol-3-amine

Guidance literature:: Multi-step reaction with 10 steps

1.1: triethylamine / 1,2-dichloro-ethane / 4 h / 23 °C

2.1: Dess-Martin periodane / 0 - 20 °C / Inert atmosphere

3.1: methanol / 2.5 h / 20 °C / Inert atmosphere

3.2: 0 - 50 °C

4.1: sodium tetrahydroborate; methanol / 0 - 20 °C / Inert atmosphere

5.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16 h / 115 °C / Inert atmosphere

6.1: hydrogen / ethanol; methanol / 16 h

7.1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane / 5 h / 20 - 40 °C / Inert atmosphere

8.1: dichloromethane / 18 h / 0 - 23 °C

9.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

9.2: 23 °C

9.3: 23 °C

10.1: hydroxylamine / ethanol / 18 h / 85 °C

With methanol; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrogen; hydroxylamine; sodium hydride; caesium carbonate; Dess-Martin periodane; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 1554015-86-9
N-(2-(4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-5-(4-(trifluoromethyl)phenyl)isoxazol-3-amine

Guidance literature:: Multi-step reaction with 10 steps

1.1: triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate; ethanol / tetrahydrofuran / 0 - 20 °C

3.1: Dess-Martin periodane / 0 - 20 °C / Inert atmosphere

4.1: hydrogenchloride / dichloromethane; water; 1,4-dioxane / 1 h / 0 °C

4.2: 1.5 h / 0 °C

5.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16 h / 115 °C / Inert atmosphere

6.1: hydrogen / ethanol; methanol / 16 h

7.1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane / 5 h / 20 - 40 °C / Inert atmosphere

8.1: dichloromethane / 18 h / 0 - 23 °C

9.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

9.2: 23 °C

9.3: 23 °C

10.1: hydroxylamine / ethanol / 18 h / 85 °C

With hydrogenchloride; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethanol; hydrogen; hydroxylamine; sodium hydride; caesium carbonate; Dess-Martin periodane; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;