(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenoic acid, methyl ester

Base Information

Chemical Name:(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenoic acid, methyl ester
CAS No.:129359-41-7
Molecular Formula:C₂₂H₂₀F₂N₂O₂
Molecular Weight:382.41
Hs Code.:

Synonyms:(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenoic acid, methyl ester

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Chemical Property of (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenoic acid, methyl ester

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Technology Process of (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenoic acid, methyl ester

There total 1 articles about (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenoic acid, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 922-67-8
propynoic acid methyl ester

: 129360-64-1
4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazole

: (Z)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenoic acid, methyl ester

: 129359-41-7
(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenoic acid, methyl ester

Guidance literature:: In tetrahydrofuran; for 65h; Heating;
DOI:10.1021/jm00075a020

Reference yield: 81.0%

: 129359-41-7
(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenoic acid, methyl ester

: 129360-69-6
(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 2h;
DOI:10.1021/jm00075a020

Reference yield:

: 129359-41-7
(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenoic acid, methyl ester

: 144501-27-9
(E,3S,5R)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / DIBAL-H / CH₂Cl₂ / 2 h / -78 °C

2: 75 percent / MnO₂ / CH₂Cl₂ / 1 h / Ambient temperature

3: 1.) lithium dicyclohexylamide / 1.) THF, hexane, 3 deg C, 2.) THF, hexane, -40 deg C

4: NaOMe / Ambient temperature

5: 1.) n-butyllithium, diisopropylamine / 1.) cyclohexane, hexane, 3 deg C, 2.) cyclohexane, hexane, THF, 3 deg C

6: 1.) methoxydiethylborane, 2.) sodium borohydride / 1.) THF, methanol, -75 deg C, 2.) THF, methanol, -75 deg C,

7: aq. NaOH / tetrahydrofuran

With manganese(IV) oxide; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; diethyl methoxy borane; sodium methylate; diisobutylaluminium hydride; lithium dicyclohexylamide; diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00075a020