ethyl 6,7,8,9-tetrahydro-2,3-dimethoxy-8-oxo-5-phenyl-5H-benzocyclohepten-5-carboxylate

Base Information

Chemical Name:ethyl 6,7,8,9-tetrahydro-2,3-dimethoxy-8-oxo-5-phenyl-5H-benzocyclohepten-5-carboxylate
CAS No.:135715-00-3
Molecular Formula:C₂₂H₂₄O₅
Molecular Weight:368.43
Hs Code.:

Synonyms:ethyl 6,7,8,9-tetrahydro-2,3-dimethoxy-8-oxo-5-phenyl-5H-benzocyclohepten-5-carboxylate

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Chemical Property of ethyl 6,7,8,9-tetrahydro-2,3-dimethoxy-8-oxo-5-phenyl-5H-benzocyclohepten-5-carboxylate

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Technology Process of ethyl 6,7,8,9-tetrahydro-2,3-dimethoxy-8-oxo-5-phenyl-5H-benzocyclohepten-5-carboxylate

There total 7 articles about ethyl 6,7,8,9-tetrahydro-2,3-dimethoxy-8-oxo-5-phenyl-5H-benzocyclohepten-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 135714-99-7
ethyl 1,2,3,4-tetrahydro-6,7-dimethoxy-4-methylene-1-phenylnaphthalene-1-carboxylate

: 135715-00-3
ethyl 6,7,8,9-tetrahydro-2,3-dimethoxy-8-oxo-5-phenyl-5H-benzocyclohepten-5-carboxylate

Guidance literature:: With iodine; silver nitrate; In methanol; water; for 0.5h; Heating;

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 135715-00-3
ethyl 6,7,8,9-tetrahydro-2,3-dimethoxy-8-oxo-5-phenyl-5H-benzocyclohepten-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 1) 98percent H₂SO₄, gl. acetic acid / 1) 70 deg C, 1.5 h, 2) reflux, overnight

2: 1) EtONa, 2) hexamethylphosphoramide / 1) THF, 0.5 h, 2) THF, rt, overnight

3: 73 percent / NaOH / ethanol; H₂O / Heating

4: 60 percent / polyphosphoric acid / 6 h / Ambient temperature

5: 56 percent / BuLi / tetrahydrofuran / Heating

6: 23 percent / AgNO₃, I₂ / methanol; H₂O / 0.5 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; PPA; sulfuric acid; iodine; sodium ethanolate; silver nitrate; acetic acid; In tetrahydrofuran; methanol; ethanol; water;

Reference yield:

: 2897-71-4
ethyl 1,2,3,4-tetrahydro-6,7-dimethoxy-4-oxo-1-phenylnaphthalene-1-carboxylate

: 135715-00-3
ethyl 6,7,8,9-tetrahydro-2,3-dimethoxy-8-oxo-5-phenyl-5H-benzocyclohepten-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / BuLi / tetrahydrofuran / Heating

2: 23 percent / AgNO₃, I₂ / methanol; H₂O / 0.5 h / Heating

With n-butyllithium; iodine; silver nitrate; In tetrahydrofuran; methanol; water;