1-(3,4-difluorophenyl)-3-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)thiourea

Base Information

Chemical Name:1-(3,4-difluorophenyl)-3-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)thiourea
CAS No.:1412891-48-5
Molecular Formula:C₂₃H₂₀F₂N₄O₂S
Molecular Weight:454.5
Hs Code.:

Synonyms:1-(3,4-difluorophenyl)-3-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)thiourea

Suppliers and Price of 1-(3,4-difluorophenyl)-3-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)thiourea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(3,4-difluorophenyl)-3-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)thiourea

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(3,4-difluorophenyl)-3-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)thiourea

There total 7 articles about 1-(3,4-difluorophenyl)-3-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.6%

: 1412891-71-4
(4-(3-aminophenoxy)pyridin-2-yl)(pyrrolidin-1-yl)methanone

: 113028-75-4
3,4-difluorophenyl isothiocyanate

: 1412891-48-5
1-(3,4-difluorophenyl)-3-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)thiourea

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2012.09.031

Reference yield:

: 591-27-5
m-Hydroxyaniline

: 1412891-48-5
1-(3,4-difluorophenyl)-3-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)thiourea

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate; potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 - 90 °C / Inert atmosphere

2: dichloromethane / 18 h / 0 - 20 °C

With potassium tert-butylate; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.09.031

Reference yield:

: 260783-12-8
4-chloro-2-pyridinecarboxylic acid pyrrolidine amide

: 1412891-48-5
1-(3,4-difluorophenyl)-3-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)thiourea

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate; potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 - 90 °C / Inert atmosphere

2: dichloromethane / 18 h / 0 - 20 °C

With potassium tert-butylate; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.09.031