(4-(3-aminophenoxy)pyridin-2-yl)(pyrrolidin-1-yl)methanone

Base Information

• Chemical Name: (4-(3-aminophenoxy)pyridin-2-yl)(pyrrolidin-1-yl)methanone
• CAS No.: 1412891-71-4
• Molecular Formula: C₁₆H₁₇N₃O₂
• Molecular Weight: 283.33
• Mol file: 1412891-71-4.mol

Synonyms:(4-(3-aminophenoxy)pyridin-2-yl)(pyrrolidin-1-yl)methanone

Chemical Property of (4-(3-aminophenoxy)pyridin-2-yl)(pyrrolidin-1-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-(3-aminophenoxy)pyridin-2-yl)(pyrrolidin-1-yl)methanone

There total 3 articles about (4-(3-aminophenoxy)pyridin-2-yl)(pyrrolidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.2%

m-Hydroxyaniline (591-27-5) + 4-chloro-2-pyridinecarboxylic acid pyrrolidine amide (260783-12-8) → (4-(3-aminophenoxy)pyridin-2-yl)(pyrrolidin-1-yl)methanone (1412891-71-4)

Guidance literature:

With potassium tert-butylate; potassium carbonate; In N,N-dimethyl-formamide; at 20 - 90 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.09.031

Reference yield:

2-Picolinic acid (98-98-6) → (4-(3-aminophenoxy)pyridin-2-yl)(pyrrolidin-1-yl)methanone (1412891-71-4)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride

2: tetrahydrofuran

3: potassium tert-butylate; potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 - 90 °C / Inert atmosphere

With thionyl chloride; potassium tert-butylate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.09.031

Reference yield:

4-Chloro-pyridine-2-carboxylic acid methyl ester (24484-93-3) → (4-(3-aminophenoxy)pyridin-2-yl)(pyrrolidin-1-yl)methanone (1412891-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran

2: potassium tert-butylate; potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 - 90 °C / Inert atmosphere

With potassium tert-butylate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.09.031

upstream raw materials:

m-Hydroxyaniline

4-chloro-2-pyridinecarboxylic acid pyrrolidine amide

2-Picolinic acid

4-Chloro-pyridine-2-carboxylic acid methyl ester

Downstream raw materials:

1-(3,4-difluorophenyl)-3-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)thiourea

1-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)thiourea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)thiourea

1-(3-((2-(pyrrolidine-1-carbonyl)pyridin-4-yl)oxy)phenyl)-3-(4-(trifluoromethoxy)phenyl)thiourea