ethyl (4R,5R)-4-[2-(benzyloxy)ethyl]-5-{1-[(S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-azatricyclo[5.2.1.0^1,5]dec-4-yl]-carbonyl}-4,5-dihydropyrazole-1-carboxylate

Base Information

• Chemical Name: ethyl (4R,5R)-4-[2-(benzyloxy)ethyl]-5-{1-[(S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-azatricyclo[5.2.1.0^1,5]dec-4-yl]-carbonyl}-4,5-dihydropyrazole-1-carboxylate
• CAS No.: 198268-11-0
• Molecular Formula: C₂₆H₃₅N₃O₆S
• Molecular Weight: 517.646

Synonyms:ethyl (4R,5R)-4-[2-(benzyloxy)ethyl]-5-{1-[(S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-azatricyclo[5.2.1.0^1,5]dec-4-yl]-carbonyl}-4,5-dihydropyrazole-1-carboxylate

Chemical Property of ethyl (4R,5R)-4-[2-(benzyloxy)ethyl]-5-{1-[(S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-azatricyclo[5.2.1.0^1,5]dec-4-yl]-carbonyl}-4,5-dihydropyrazole-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (4R,5R)-4-[2-(benzyloxy)ethyl]-5-{1-[(S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-azatricyclo[5.2.1.0^1,5]dec-4-yl]-carbonyl}-4,5-dihydropyrazole-1-carboxylate

There total 8 articles about ethyl (4R,5R)-4-[2-(benzyloxy)ethyl]-5-{1-[(S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-azatricyclo[5.2.1.0^1,5]dec-4-yl]-carbonyl}-4,5-dihydropyrazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

chloroformic acid ethyl ester (541-41-3) + (S)-4-[(E)-5-(benzyloxy)pent-2-enoyl]-10,10-dimethyl-3λ6-thia-4-azatricyclo[5.2.1.01,5]decane-3,3-dione (198268-10-9) + diazomethyl-trimethyl-silane (18107-18-1) → ethyl (4S,5S)-4-[2-(benzyloxy)ethyl]-5-{1-[(S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-azatricyclo[5.2.1.01,5]dec-4-yl]-carbonyl}-4,5-dihydropyrazole-1-carboxylate + ethyl (4R,5R)-4-[2-(benzyloxy)ethyl]-5-{1-[(S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-azatricyclo[5.2.1.01,5]dec-4-yl]-carbonyl}-4,5-dihydropyrazole-1-carboxylate (198268-11-0)

Guidance literature:

(S)-4-[(E)-5-(benzyloxy)pent-2-enoyl]-10,10-dimethyl-3λ⁶-thia-4-azatricyclo[5.2.1.0^1,5]decane-3,3-dione; diazomethyl-trimethyl-silane; With molecular sieve; In hexane; dichloromethane; at 23 ℃; for 90h;

chloroformic acid ethyl ester; With silver trifluoromethanesulfonate; In dichloromethane; at 0 ℃; for 1.5h;

DOI:10.1002/1522-2675(20000809)83:8<2007::AID-HLCA2007>3.0.CO;2-5

Reference yield: 71.0%

chloroformic acid ethyl ester (541-41-3) + [4-(2-Benzyloxy-ethyl)-5-trimethylsilanyl-4,5-dihydro-3H-pyrazol-3-yl]-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone → ethyl (4S,5S)-4-[2-(benzyloxy)ethyl]-5-{1-[(S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-azatricyclo[5.2.1.01,5]dec-4-yl]-carbonyl}-4,5-dihydropyrazole-1-carboxylate + ethyl (4R,5R)-4-[2-(benzyloxy)ethyl]-5-{1-[(S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-azatricyclo[5.2.1.01,5]dec-4-yl]-carbonyl}-4,5-dihydropyrazole-1-carboxylate (198268-11-0)

Guidance literature:

With silver trifluoromethanesulfonate;

DOI:10.1021/jo971571l

Reference yield:

(S)-4-[(E)-5-(benzyloxy)pent-2-enoyl]-10,10-dimethyl-3λ6-thia-4-azatricyclo[5.2.1.01,5]decane-3,3-dione (198268-10-9) → ethyl (4R,5R)-4-[2-(benzyloxy)ethyl]-5-{1-[(S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-azatricyclo[5.2.1.01,5]dec-4-yl]-carbonyl}-4,5-dihydropyrazole-1-carboxylate (198268-11-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hexane; CH₂Cl₂

2: 71 percent / AgOTf

With silver trifluoromethanesulfonate; In hexane; dichloromethane;

DOI:10.1021/jo971571l

upstream raw materials:

chloroformic acid ethyl ester

(S)-4-[(E)-5-(benzyloxy)pent-2-enoyl]-10,10-dimethyl-3λ⁶-thia-4-azatricyclo[5.2.1.0^1,5]decane-3,3-dione

diazomethyl-trimethyl-silane

5-benzyloxy-2-(E)-pentenocarboxylic acid

Downstream raw materials:

ethyl (4S,5R)-4-[2-(benzyloxy)ethyl]-4,5-dihydro-5-(hydroxymethyl)pyrazole-1-carboxylate

(1S,8aS)-1-[2-(benzyloxy)ethyl]-1,5,8,8a-tetrahydro-pyrazolo[1,5-a]pyridine

ethyl (4S,5R)-4-[2-(benzyloxy)ethyl]-5-formyl-4,5-dihydropyrazole-1-carboxylate

(S)-N-[(R)-4-(benzyloxy)-2-(piperidin-2-yl)butyl]-2,2,2-trifluoroacetamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 198268-11-0 ethyl (4R,5R)-4-[2-(benzyloxy)ethyl]-5-{1-[(S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-azatricyclo[5.2.1.0^1,5]dec-4-yl]-carbonyl}-4,5-dihydropyrazole-1-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send