[(Z)-Tetrahydro-pyran-2-yloxyimino]-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-acetic acid

Base Information

Chemical Name:[(Z)-Tetrahydro-pyran-2-yloxyimino]-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-acetic acid
CAS No.:75626-68-5
Molecular Formula:C₁₅H₁₅F₃N₂O₅
Molecular Weight:360.29
Hs Code.:

Synonyms:[(Z)-Tetrahydro-pyran-2-yloxyimino]-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-acetic acid

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Chemical Property of [(Z)-Tetrahydro-pyran-2-yloxyimino]-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-acetic acid

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Technology Process of [(Z)-Tetrahydro-pyran-2-yloxyimino]-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-acetic acid

There total 10 articles about [(Z)-Tetrahydro-pyran-2-yloxyimino]-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 75626-63-0
[(Z)-Tetrahydro-pyran-2-yloxyimino]-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-acetic acid methyl ester

: 75626-68-5
[(Z)-Tetrahydro-pyran-2-yloxyimino]-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-acetic acid

Guidance literature:: With lithium iodide; In pyridine; at 90 - 100 ℃; for 4h;
DOI:10.1021/jo00314a029

Reference yield:

: 72531-10-3
4-<<(benzyloxy)carbonyl>amino>acetophenone

: 75626-68-5
[(Z)-Tetrahydro-pyran-2-yloxyimino]-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / selenium dioxide / 3 h / 100 °C

2: 59 percent / pyridine / 4 h / 0 °C

3: 98 percent / methanol; diethyl ether / 0 °C

4: 100 percent / H₂ / palladium on carbon / ethyl acetate / 0.5 h

5: 83 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

6: 68 percent / lithium iodide / pyridine / 4 h / 90 - 100 °C

With selenium(IV) oxide; hydrogen; triethylamine; lithium iodide; palladium on activated charcoal; In pyridine; methanol; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jo00314a029

Reference yield:

: 75626-51-6
4-<<(benzyloxy)carbonyl>amino>-α-oxophenylacetic acid

: 75626-68-5
[(Z)-Tetrahydro-pyran-2-yloxyimino]-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 59 percent / pyridine / 4 h / 0 °C

2: 98 percent / methanol; diethyl ether / 0 °C

3: 100 percent / H₂ / palladium on carbon / ethyl acetate / 0.5 h

4: 83 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

5: 68 percent / lithium iodide / pyridine / 4 h / 90 - 100 °C

With hydrogen; triethylamine; lithium iodide; palladium on activated charcoal; In pyridine; methanol; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jo00314a029