(S)-1-(N-tert-butoxycarbonyl-D-Tic-4-Cl-D-Phe)-4-{2-[1-((tert-butyldimethylsilanyl)oxy)ethyl]phenyl}piperazine

Base Information

Chemical Name:(S)-1-(N-tert-butoxycarbonyl-D-Tic-4-Cl-D-Phe)-4-{2-[1-((tert-butyldimethylsilanyl)oxy)ethyl]phenyl}piperazine
CAS No.:444583-93-1
Molecular Formula:C₄₂H₅₇ClN₄O₅Si
Molecular Weight:761.477
Hs Code.:

Synonyms:(S)-1-(N-tert-butoxycarbonyl-D-Tic-4-Cl-D-Phe)-4-{2-[1-((tert-butyldimethylsilanyl)oxy)ethyl]phenyl}piperazine

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Chemical Property of (S)-1-(N-tert-butoxycarbonyl-D-Tic-4-Cl-D-Phe)-4-{2-[1-((tert-butyldimethylsilanyl)oxy)ethyl]phenyl}piperazine

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Technology Process of (S)-1-(N-tert-butoxycarbonyl-D-Tic-4-Cl-D-Phe)-4-{2-[1-((tert-butyldimethylsilanyl)oxy)ethyl]phenyl}piperazine

There total 7 articles about (S)-1-(N-tert-butoxycarbonyl-D-Tic-4-Cl-D-Phe)-4-{2-[1-((tert-butyldimethylsilanyl)oxy)ethyl]phenyl}piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 444581-58-2
(S)-N-{2-[1-((tert-butyldimethylsilanyl)oxy)ethyl]phenyl}piperazine

: 252008-71-2
(N-tert-butoxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-4-chloro-D-phenylalanine

: 444583-93-1
(S)-1-(N-tert-butoxycarbonyl-D-Tic-4-Cl-D-Phe)-4-{2-[1-((tert-butyldimethylsilanyl)oxy)ethyl]phenyl}piperazine

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm0304109

Reference yield:

: 78879-20-6,144069-68-1,115962-35-1
D-N-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinolinoline-3-carboxylic acid

: 444583-93-1
(S)-1-(N-tert-butoxycarbonyl-D-Tic-4-Cl-D-Phe)-4-{2-[1-((tert-butyldimethylsilanyl)oxy)ethyl]phenyl}piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / 4-(dimethylamino)pyridine; 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide*HCl / CH₂Cl₂ / 0 - 20 °C

2: aq. NaOH / methanol / 0 - 25 °C

3: 1-hydroxy-7-azabenzotriazole; diisopropylethylamine; O-(7-azobenzotriazol-1-yl)-1,1,3,3-tetramethyluronium PF₆ / CH₂Cl₂; dimethylformamide / 20 °C

With dmap; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0304109

Reference yield:

: 5411-56-3,76116-20-6,118375-26-1,114446-55-8
(1S)-1-(2-bromophenyl)ethanol

: 444583-93-1
(S)-1-(N-tert-butoxycarbonyl-D-Tic-4-Cl-D-Phe)-4-{2-[1-((tert-butyldimethylsilanyl)oxy)ethyl]phenyl}piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / imidazole / dimethylformamide

2: tris(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; sodium t-butoxide / toluene / 100 °C

3: 1-hydroxy-7-azabenzotriazole; diisopropylethylamine; O-(7-azobenzotriazol-1-yl)-1,1,3,3-tetramethyluronium PF₆ / CH₂Cl₂; dimethylformamide / 20 °C

With 1H-imidazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; HATU; sodium t-butanolate; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0304109