Technology Process of ethyl 3-((6-(2,6-dimethylphenyl)-3-fluoropyridin-2-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5] cyclopenta[1,2-c]pyridine-6-carboxylate
There total 13 articles about ethyl 3-((6-(2,6-dimethylphenyl)-3-fluoropyridin-2-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5] cyclopenta[1,2-c]pyridine-6-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
silver carbonate;
In
toluene;
at 100 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / 12 h / 70 °C / 2585.81 Torr
2.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 20 °C
2.2: 1 h
3.1: palladium on activated charcoal; hydrogen / methanol / 2.5 h / 20 °C / 1551.49 Torr
4.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C
5.1: toluene-4-sulfonic acid / dimethyl sulfoxide; water / 2 h / 150 °C
6.1: methanol; sodium tetrahydroborate / 2 h / 0 - 20 °C
7.1: magnesium sulfate; Methyl p-tolyl sulfone / toluene / 2 h / 110 °C
8.1: dirhodium tetraacetate / dichloromethane / 8 h
9.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 2 h / Reflux
10.1: silver carbonate / toluene / 12 h / 100 °C
With
methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dirhodium tetraacetate; sodium tetrahydroborate; chloro-trimethyl-silane; palladium on activated charcoal; hydrogen; sodium hexamethyldisilazane; sodium hydride; magnesium sulfate; toluene-4-sulfonic acid; triethylamine; Methyl p-tolyl sulfone; silver carbonate; sodium iodide;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) / tetrahydrofuran; water / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation
2: selenium(IV) oxide / 1,4-dioxane / 12 h / 100 °C
3: methanol; sodium tetrahydroborate / 1 h / 0 °C
4: phosphorus tribromide / tetrahydrofuran / 3 h / 0 - 20 °C
5: silver carbonate / toluene / 12 h / 100 °C
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; methanol; selenium(IV) oxide; sodium tetrahydroborate; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); phosphorus tribromide; silver carbonate;
In
tetrahydrofuran; 1,4-dioxane; water; toluene;
